Sintesis dan Potensi Aktivitas Tabir Surya Senyawa Analog Kalkon Turunan 3’-Hidroksiasetofenon dan 4-Metoksibenzaldehid

Ihsan Ikhtiarudin (Sekolah Tinggi Ilmu Farmasi Riau)
Nesa Agistia (Sekolah Tinggi Ilmu Farmasi Riau)
Tria Harlianti (Sekolah Tinggi Ilmu Farmasi Riau)
Adel Zamri (Jurusan Kimia, FMIPA, Universitas Riau)

JURNAL PHOTON
Vol 10 No 1 (2019): Jurnal Photon

Chalcone analogues have attracted the attention of researchers due to their various biological activities. In this study, a chalcone analogue, (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has been synthesized under microwave irradiation and its sunscreen activity has been evaluated by in vitro assay using 96-well microplate reader. Based on the in vitro assay, at concentration of 100-500 µg/ml, the compound showed potential sunscreen activity with %Te value of 5.49 – 0.04 % (extra protection – sunblock), %Tp value of 0.51-0.05 % (sunblock) and SPF value of 18.20 – 32.91 (ultra protection). The assay result showed that the (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has a potency to be developed as active ingredient in sunscreen product.