Seleksi Parameter yang Mempengaruhi Sintesis Kalkon dengan Metode Plackett-Burman

Indah Silvia Sugiyamin (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis” Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Harra Ismi Farah (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis” Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Agung Rahmadani (Program Studi Pendidikan Kimia, Universitas Mulawarman, Jalan Muara Pahu, Samarinda, 75119, Kalimantan Timur, Indonesia & Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis” Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indon)
Angga Cipta Narsa (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis” Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)

Proceeding of Mulawarman Pharmaceuticals Conferences
Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences

Chalcone is a compound that has various biological activities. The organic synthesis approach has been widely used to obtain chalcone compouds. The aim of this research is to select the main parameters which influence chalcone synthesis. This study was conducted using Plackett-Burman experimental design. Of eleven parameters used, eight of them showed a significant effect on the yield of chalcones namely temperature, reaction time, mole number of benzaldehyde, volume of acetophenone solvent, incubation time, volume of distilled water, volume of benzaldehyde solvent, catalyst volume and dummy. In addition, the highest yield is 32.43%.