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All Journal Proceeding of Mulawarman Pharmaceuticals Conferences
Harra Ismi Farah
Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis” Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Seleksi Parameter yang Mempengaruhi Sintesis Kalkon dengan Metode Plackett-Burman Indah Silvia Sugiyamin; Harra Ismi Farah; Agung Rahmadani; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.386 KB) | DOI: 10.25026/mpc.v11i1.385

Abstract

Chalcone is a compound that has various biological activities. The organic synthesis approach has been widely used to obtain chalcone compouds. The aim of this research is to select the main parameters which influence chalcone synthesis. This study was conducted using Plackett-Burman experimental design. Of eleven parameters used, eight of them showed a significant effect on the yield of chalcones namely temperature, reaction time, mole number of benzaldehyde, volume of acetophenone solvent, incubation time, volume of distilled water, volume of benzaldehyde solvent, catalyst volume and dummy. In addition, the highest yield is 32.43%.
Co-Authors Angga Cipta Narsa Indah Silvia Sugiyamin Rahmadani, Agung