Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon

Amanuddin Amanuddin (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Hanggara Arifian
Agung Rahmadani (Program Studi Pendidikan Kimia, Universitas Mulawarman, Jalan Muara Pahu, Samarinda, 75119, Kalimantan Timur, Indonesia & Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indo)
Rolan Rusli (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)

Proceeding of Mulawarman Pharmaceuticals Conferences
Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences

Chalcone are compounds that have 2 aromatic rings connected by 3 carbon atoms which are an ?, ? unsaturated carbonyl system that have various biological activities. 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone was synthesized from 2'-hydroxy-5'-chloro acetophenone and syringaldehyde using a NaOH catalyst. This compound was purified using Column Chromatography by isocratic method using n-hexane:ethyl acetate (15:1) as eluent. This compound has a Rf 0.75 and 2.7% of yield.