Proceeding of Mulawarman Pharmaceuticals Conferences
Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences

Pengaruh Trietanolamin pada Basis Krim Minyak dalam Air yang Berbahan Dasar Asam Stearat dan Setil Alkohol: Effect of Triethanolamine on Oil-in-Water Cream Base Based on Stearic Acid and Cetyl Alcohol

Novita Sari (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Erwin Samsul (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Angga Cipta Narsa (Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)



Article Info

Publish Date
31 Dec 2021

Abstract

The cream is a semi-solid preparation with one or more ingredients dispersed in two types of emulsions, water-in-oil (W/O) and oil-in-water (O/W) type creams. Oil-in-water type cream has a high water content so that it can provide a hydration effect that can increase the penetration of the active substance. Triethanolamine in topical preparations is used as an emulsifier and alkalizing agent to form a homogeneous and stable cream. The purpose of this research was to determine the effect of triethanolamine on an oil-in-water cream base based on stearic acid and cetyl alcohol. Making the base is done by making preparations using four concentrations of triethanolamine 0.5% (F1), 1% (F2), 1.5% (F3), and 2% (F4). The cream base was then evaluated for its physical properties including organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, and phase separation test. The results showed that in the organoleptic test cream bases were white, had a characteristic aroma with a semisolid form. The cream base has a homogeneity dispersion with an average pH between 6.53-7.29, viscosity between 3.5792396-3.8001904 (Pa.s), spreadability between 5.43-5.78 cm, and adhesion between 4.47-6.25 seconds. The cream base did not have phase separation and was stable in storage for 4 weeks at room temperature.

Copyrights © 2021






Journal Info

Abbrev

mpc

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan ...