Liver and Renal Cell Damage Following Excess Bee Honey Consumption in Male Wistar Rat

Akpevwoghene Agbatutu (Department of Botany, University of Ibadan)
Jerome Ndudi Asiwe (Department of Physiology, PAMO University of Medical Sciences, Port-Harcourt.)
Olusegun Gafar Adebayo (Department of Physiology, PAMO University of Medical Sciences. Port-Harcourt.)

Biology, Medicine, & Natural Product Chemistry
Vol 11, No 1 (2022)

Honey is a widely used natural product with several health benefits. However, there is paucity of information on its excessive usage. The present study investigated the effect of excess honey consumption on hepato-renal functions in male wistar rats. Twenty-eight adult male Wistar rats were selected into four groups (n=7) and treated with distilled water (control) and 1ml, 2ml and 3ml of honey respectively for 5 weeks. Thereafter, the animals were euthanised and blood as well as kidney and liver were collected for further studies. There was a significant increase in Creatinine, Bilirubin, Urea AST, ALP, total protein as well as a significant decrease in RBC, WBC, haemoglobin, lymphocyte and PCV. Histology of the liver and kidney revealed a significant degeneration and necrosis in a dose dependent manner. This study suggest that excess honey consumption causes liver and renal cellular damage as well as haematological alterations.