Efek Teratogenik Ekstrak Etanol Kulit Batang Pule (Alstonia scholaris R.Br) pada Tikus Wistar

Endang Kumolosasi ( UBI Farmasi Rumah Sakit/Farmakologi-Toksikologi ITB)
Andreanus A. Soemardji ( UBI Farmakologi-Toksikologi ITB)
Komar Ruslan W. ( UBI Farmakognosi-Fitokimia, Departemen Farmasi FMIPA-ITB)
Hasti Yuliani ( UBI Farmakologi-Toksikologi, FMIPA-ITB)

Jurnal Matematika & Sains
Vol 9, No 2 (2004)

The teratogenic effect of ethanolic extract of “pule” (Alstonia scholaris R.Br., Apocynaceae) bark at repeated doses of 490 and 980 mg/kg body weight administered orally to pregnant Wistar rats for 19 days had been studied. Each dose caused miscarriage in 9.1% of the rats and mild hydrocephalus in 23.1% of the fetuses (dose 490 mg/kg body weight) and in 12.0% of the fetuses (dose 980 mg/kg body weight).