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All Journal Jurnal Matematika & Sains Acta Pharmaceutica Indonesia Journal of Medicine and Health JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Sains dan Kesehatan Journal of Medicine and Health
Andreanus A. Soemardji
UBI Farmakologi-Toksikologi ITB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Public Health

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Toksisitas Akut dan Penentuan DL50 Oral Ekstrak Air Daun Gandarusa (Justicia gendarussa Burm. F.) pada Mencit Swiss Webster Andreanus A. Soemardji; Endang Kumolosasi; Cucu Aisyah
Jurnal Matematika & Sains Vol 7, No 2 (2002)
Publisher : Institut Teknologi Bandung

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Abstract

Acute toxicity test of water extract of “gandarusa” (Justicia gendarussa Burm F.) leaves in Swiss Webster mice and oral median lethal dose (LD50) determination by four methods had been performed. Results showed that “gandarusa” leaves have toxic effect on central nerveus system. Oral LD50 by Miller-Tainter method, Reed-Muench method, Kärber method, and calculation method of Farmakope Indonesia 3rd edition in male mice had the same value as that in female mice i.e. 21.00, 21.03, 22.50, and 21.60 g/kg body weight respectively. Miller-Tainter method produced the lowest LD50 value.
Efek Teratogenik Ekstrak Etanol Kulit Batang Pule (Alstonia scholaris R.Br) pada Tikus Wistar Endang Kumolosasi; Andreanus A. Soemardji; Komar Ruslan W.; Hasti Yuliani
Jurnal Matematika & Sains Vol 9, No 2 (2004)
Publisher : Institut Teknologi Bandung

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The teratogenic effect of ethanolic extract of “pule” (Alstonia scholaris R.Br., Apocynaceae) bark at repeated doses of 490 and 980 mg/kg body weight administered orally to pregnant Wistar rats for 19 days had been studied. Each dose caused miscarriage in 9.1% of the rats and mild hydrocephalus in 23.1% of the fetuses (dose 490 mg/kg body weight) and in 12.0% of the fetuses (dose 980 mg/kg body weight).
Aktivitas Ekstrak Ethanol Daun, Ranting, dan Kulit Buah Manggis (Garcinia mangostana l.) sebagai Tabir Surya secara in vitro - Liandhajani; Maria Immaculata Iwo; - Sukrasno; Andreanus A. Soemardji; I Ketut Adnyana
Acta Pharmaceutica Indonesia Vol. 36 No. 1 & 2 (2011)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Telah banyak penelitian yang dilakukan pada buah Manggis (Garcinia mangostana L.) , kayu maupun kulit buahnya sebagai pengobatan, antara lain diare, antiinflamasi, HIV. Hal ini sehubungan dengan kandungan manggis yang beragam. Zat aktif yang terkandung dalam manggis sangat banyak antara lain tanin, xanthone dan bensofenon glukosida yaitu garmacimangasone D. Kandungan turunan bensofenone diduga mempunyai aktivitas sebagai tabir surya. Dari penelitian sebelumnya telah diketemukan turunan bensofenone dalam kulit buah manggis dan kayunya. Turunan bensofenone telah dimanfaatkan sebagai tabir surya pada sediaan kosmetika, dengan demikian diharapkan turunan bensofenon yang ada dalam manggis (Garcinia mangostana L.) mempunyai juga aktivitas sebagai tabir surya. Pada penelitian ini dilakukan uji aktivitas tabir surya pada daun, ranting, dan kulit buah manggis. Mula-mula dilakukan ekstraksi maserasi dengan menggunakan etanol pada simplisia daun, ranting, dan kulit buah manggis. Penetapan ekstrak aktifitas tabir surya yaitu dengan menggunakan spektrofotometer pada panjang gelombang 290 hingga 400 nm menggunakan pelarut etanol. Dari peneltian yang telah dilakukan nilai sun protection factor (SPF) ekstrak kulit buah, ranting, dan daun manggis pada konsentrasi 50 μg/ ml adalah 1,967 (pada panjang gelombang 290-382,5 nm); 1,356 (290-332,5 nm) ; 1,286 (290-327.5 nm). Dengan demikian ekstrak kulit buah manggis mempunyai SPF yang relatif lebih tinggi dibanding ranting maupun daunnya.
STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Andreanus A. Soemardji; Ita N. Anisa; Nareswari Alka Damayanti
Journal of Medicine and Health Vol. 1 No. 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.511 KB) | DOI: 10.28932/jmh.v1i2.513

Abstract

“Rumput Mutiara” or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, β-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, “baihua she she cao su” (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.  Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb. Keywords:  Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.
PENGARUH PEMBERIAN DAGING SIPUT SAWAH (Filopaludina javanica v.d Busch 1844)TERHADAP PENYEMBUHAN TUKAK LAMBUNG PADA TIKUS WISTAR BETINA YANG DIINDUKSI ASETOSAL Rizka Mulya Miranti; Andreanus A. Soemardji; Siti Kusmardiyani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 1 (2020): September 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

ABSTRAK Siput sawah (Filopaludina javanica v.d Busch 1844) telah digunakan oleh masyarakat Jawa Barat untuk mengobati tukak lambung secara empiris, namun belum ada penelitian yang membuktikan efek tersebut. Pengujian ini merupakan pengujian farmakologi yang bertujuan mengetahui penurunan indeks tukak lambung pada tikus yang diinduksi asetosal. Induksi asetosal dosis 405 mg/kg diberikan selama 10 hari. Daging siput sawah yang telah direbus diberikan selama tiga hari dengan dosis 3,310 g/kg dan dosis 6,620 g/kg. Obat pembanding yang digunakan adalah Lansoprazol dosis 5 mg/kg. Hasil pengujian menunjukan bahwa persentasi penyembuhan dosis 3,310 g/kg adalah sebesar 4,92 % dan dosis 6,620 g/kg sebesar 8,20 %. Indeks tukak lambung pada tikus kelompok uji lebih rendah dari kelompok kontrol positif dengan signifikasi P>0,05. Kata kunci : Siput sawah, Filopaludina javanica v.d Busch 1844, antitukak lambung, asetosal ABSTRACT People in West Java consume rice field snail (Filopaludina javanica v.d Busch 1844) to treat peptic ulcers but no scientific studies have proven that effect. This research is a pharmacological test that aims to determine the reduction in the index of peptic ulcers in mice indusced by acetosal. Rat-peptic ulcer model was induced with acetosal 405 mg/kg body weight for 10 days. Boiled rice snail meat is given for three days at a dose of 3,310 g / kg and a dose of 6,620 g / kg. The comparison drug used is Lansoprazol dose of 5 mg / kg. The results showed that the gastric ulcer healing dose 3,310 g/kg and 6,620 g/kg were 4,92% and 8,20%. Peptic ulcer index in the test group mice was lower than the positive control group even though there was no significant difference (P> 0.05). Keyword: Rice field snail, Filopaludina javanica v.d. Busch 1844, Peptic ulcer activity, Acetosal
Aktivitas Antidiabetes Serbuk Semut Jepang (Tenebrio molitor Linn.) pada Mencit Swiss Webster Jantan yang Diinduksi Aloksan Erwin Samsul; Andreanus A. Soemardji; Siti Kusmardiyani
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.150

Abstract

Diabetes mellitus is a disease caused by metabolic disorders with hyperglycemia conditions that can occur due to impaired insulin secretion, insulin sensitivity or both. Semut Jepang (SJ) are used by people of Indonesians as a drug to reduce blood sugar levels, but have not been scientifically studied as antidiabetic. Therefore, this study aims to examine the antidiabetic activity of Japanese ant powder in mice. Method: The study was carried out using the antihyperglycemic method in mice induced by alloxan. In the antihyperglycemic method in alloxan induced mice, mice were divided into 6 groups, namely 1% normal Na CMC control group (not alloxan induced), 1% Na CMC pain control group (alloxan induced), glibenclamide 5 mg / kg bw comparison group, and 3 test groups were given Japanese ant powder with a dose of 9 mg / kg bw (SJ 9), 45 mg / kg bw (SJ 45), and 90 mg / kg bw (SJ 90). Blood glucose levels were measured on the first day, day 3, day 7, and day 14. Results: The use of SJ 45 and SJ 90 were better in lower blood glucose compared to the glibenclamide comparison group. Conclusion: Japanese ant powder at doses of 45 and 90 mg / kg bw give an antidiabetic effect that is better than glibenklamid 5 mg / kg bw in reducing blood glucose levels in mice induced by alloxan. Keyword : Semut jepang powder, diabetes mellitus, blood glucose level
STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Andreanus A. Soemardji; Ita N. Anisa; Nareswari Alka Damayanti
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.513

Abstract

“Rumput Mutiara” or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, β-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, “baihua she she cao su” (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.  Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb. Keywords:  Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.
Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Meilinah Hidayat; Sijani Prahastuti; Vibiola Chikita; Dewi Safitri; Siti F. Rahmawati; Andreanus A. Soemardji
Journal of Medicine and Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i4.530

Abstract

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.  This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretation’s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJB  have a good effect on kidney function, did  not lead to changes in organ weight and at low doses did not cause disturbance of  renal histopathology. Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidney’s  weight, kidney’s histopathology
Co-Authors - Liandhajani - Sukrasno Cucu Aisyah Dewi Safitri Endang Kumolosasi Erwin Samsul Hasti Yuliani I Ketut Adnyana Ita N. Anisa Komar Ruslan W. Maria Immaculata Iwo Meilinah Hidayat Nareswari Alka Damayanti Rizka Mulya Miranti Samsul, Erwin Sijani Prahastuti Siti F. Rahmawati Siti Kusmardiyani Vibiola Chikita