Jurnal AFAMEDIS
Vol. 2 No. 1 (2021): Jurnal Farmasi Indonesia Afamedis

Pengaruh Variasi Konsentrasi Polivinil Pirolidon K-30 sebagai Pengikat dalam Pembuatan Oral Fast Dsissolving Tablet Domperidon Base

Deny budi legowo (Akademi Farmasi Mitra Sehat Mandiri Sidoarjo)
Riski Ramadhan (Akademi Farmasi Mitra Sehat Mandiri Sidoarjo)
Erna Fitriany (Akademi Farmasi Mitra Sehat Mandiri Sidoarjo)
Indah Tri Lestari (Universitas Darussalam Gontor)



Article Info

Publish Date
28 Feb 2021

Abstract

Domperidone base as anti-nausea or vomiting drug mostly available in conventional tablets forms has weakness in swallowing tablets and requires drinking water. Oral fast dissolving tablets are a solution to this problem. Oral fast dissolving tablets with variations in the concentration of PVP K-30 to determine effect of the tablet physical quality test and good physical quality results. The wet granulation method was used to improve the flow properties by mixing the binder mucilago with the inner phase. Test of physical quality of tablets, weight uniformity, size uniformity, hardness, friability, disintegration time, and unifomity of content. The results showed a significant difference in friability and disitegration time. The conclusion based on the results of the study showed that the variation in the concentration of PVP K-30 on the difference in the physical quality test of tablets and the 2% concentration of PVP K-30 gave good results

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Journal Info

Abbrev

afamedis

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Indonesia AFAMEDIS (ISSN: 2721-3269) adalah jurnal akses terbuka dan peer-review yang diterbitkan oleh Akademi Farmasi Mitra Sehat Mandiri Sidoarjo. Jurnal ini diterbitkan dua kali per tahun pada bulan Februari dan Agustus. Jurnal Farmasi Indonesia AFAMEDIS menerbitkan artikel ...