Microstructural Analysis and Antibacterial Response of Zn2+/Mg2+ Dual Doped β-Tricalcium Phosphate Bioceramics

Ammar Zeidan Alshemary (Department of Biomedical Engineering, Faculty of Engineering, Karabuk University, Karabuk 78050, Turkey Biomedical Engineering Department, Al-Mustaqbal University College, Hillah, Babil 51001, Iraq)
Huda Basim Qasim (Al-Manara College for Medical Sciences, Misan 62001, Iraq)
Ali Taha Saleh (Department of Chemistry, College of Science, University of Misan, Misan 62001, Iraq)

Indonesian Journal of Chemistry
Vol 22, No 2 (2022)

This article evaluates the impact of the addition of zinc (Zn) and magnesium (Mg) on the structural, morphological, and antibacterial characteristics of β-tricalcium phosphates (hereafter called Zn/Mg-βTCP) prepared using the microwave (MW) assisted wet precipitation method in which the Ca deficient apatite [Ca9-(x+y)MgxZny(HPO4)(PO4)5 (OH)] was calcined for 2 h at 1000 °C. The prepared samples were characterized using XRD, FTIR, and FESEM measurements. The XRD patterns of the samples showed a steady decrease in the lattice parameters with an increase in Mg2+ and Zn2+ content. The FESEM images of the samples disclosed the morphological changes due to the Mg2+/Zn2+ co-doping. The inclusion of Mg2+ and Zn2+ into the βTCP was shown to induce excellent bioactivities that were absent in the pristine βTCP. Enhancement, coupled with good antimicrobial properties against Escherichia coli (E. coli), suggests that Mg2+/Zn2+ co-doping TCP can be developed further into antibacterial bone cement. As synthesized, it would be considered a potential biomaterial for orthopedic applications.