Biological control represents an important approach for controlling many pathogenic fungi. Pleurotusostreatus is the most promising and effective bioagents against many pathogenic fungi. In this paper seventyclinical specimens were collected from hospitalized patients, who were aged between (1 and 71) years oldfor both genders. The results of this study showed that out of 70 specimens that collected from urine, Skin,Vaginal and Oral specimens, (61) specimens (87.14%) were positive for fungal infections and (9) specimens(12.86%) were negative. Out of (61) positive specimens, (50) specimens (82%) were positive for Candidaspp, (7) specimens (11%) were Trichophyton spp and (4) specimens (7%) were Microsporum spp. Out of(50) positive specimens for candidal infections, Candida albicans was the more prevalence fungus (66%)followed by the fungus Candida glabrata (14%). The maximum infection incidence has been recorded inthe age group of (21- 40) years and the women have been considerably more than the male in all testedage groups. Pleurotus ostreatus culture filtrate affected the growth of Candida spp and the effect had beenincreased with the increasing of the filtrate concentrations. The more sensitive species was C. tropicalis andC. krusei than the other species.
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