<![CDATA[This study to provide details on role of Acrylonitrile (AN) in blood profile and histopathological changes inliver in male albino mice, the aims of current study were detected influence and toxication of AN in the malemice, the present article was include (30 albino mice) divided into 3 groups, the age ranged from 8-9 week.The dose of Acrylonitrile (25mg / kg of BW) and the period of this study 60 days.The hematological examination showed increased in WBCs (9.32±1.11 / 11.802±0.75), Lymphocyte(9.25±2.20 / 11.05±1.95), Neutrophile (5.55±0.88 / 7.03±1.50) and Monocyte (0.19±0.97 / 0.33±0.18) in2nd and 3rd group respectively, while showed decreased in RBCs (6.40±1.11 / 5.82±0.70), PCV (38.65±1.20/ 36.40±2.13), MCV (44.70±1.49 /41.95±0.49), MCH (14.85±1.44 / 10.00±1.84) and Hb (13.24±1.82 /12.63±1.91) in 2nd and 3rd group respectively, The histopathological changes in liver showed extensivenecrosis, thickening and congestion of blood vessels, infiltration of inflammatory cells, mast cell aggregationin hepatocytes, hepatocyte atrophy and extensive areas of abscess in 2nd group, while in 3rd group showedperihyperplastic bile duct, large extensive granuloma, multiple giant cells, dystrophic calcified and hepaticnecrosis.]]>
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