<![CDATA[India alone accounts for one third of the world’s oral cancer and has a high rate of Oral Potentially MalignantDiseases (OPMD) amongst Areca Nut & Tobacco Habitual. Oral submucous fibrosis (OSMF) is one ofthe OPMDs which predominantly affect major population of South and Southeast Asia, especially Indiansubcontinent. Till date OSMF patients are treated symptomatically to relieve burning sensation, improve theopening of mouth & tongue movements, reduce blanching and relieve from roughness of oral mucosa byusing various medicinal line of treatment i.e. vitamin A, lycopene, beta carotene and carotene analogs, but notreatment is directed towards the reduction of malignant potential of preexisting OSMF cases. Thus, presentstudy will be conducted to compare the pre & post treatment serum level of proliferation, angiogenesis andapoptosis inducing expression of markers with polyherbal therapy in oral submucous fibrosis. Methods:Identification of clinically diagnosed patients of OSMF who will be divided into two groups by simplerandom sampling procedure. Group-1 patients suffering from oral submucous fibrosis, will be receivingPolyherbal Preparation while Group-2 patients receiving Lycopene. Pre and post treatment comparison forclinical signs and symptoms and serum marker expressions for Proliferation, Angiogenesis, & Apoptosis inboth groups will be done and statistically analyzed. Results: Clinical signs and symptoms will be improvedwith the present polyherbal protocol. Post treatment serum marker may favored reduction in proliferation,angiogenesis and induced apoptosis which predicts malignant transformation. Conclusions: Polyherbaltherapy will help to reduce the malignant conversion without toxic effect on other system of the human body]]>
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