Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology

Study the Negative Effects of Pseudoephedrine on Brain Tissues in Adult Albino Male Rats

Raghad Hazem Hamad Al-Abbasi (Unknown)
Muneef Saab Ahmad Al-Janabi (Unknown)
Iyad Hamid Ibrahim (Unknown)



Article Info

Publish Date
24 Mar 2021

Abstract

In this study, (24) male animals were used, which were divided randomly into four groups. Each groupincluded (6) animals, which are: the control group that was given drinking water and food daily, and thegroup of rats treated with pseudoephedrine at a dose of (40) mg / Kg of body weight for a period of (30)days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for a periodof (40) days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for aperiod of (50) days, the animals dosed the drug by the oropharyngeal tube at a dose of (1) ml, and after theend of the experiment, the animals were scarified , brain samples were taken and preserved with formalinat a concentration of 10% until the tissue sections were made, when the meningeal membrane appeared theupper layers of the cerebral cortex in the group treated with pseudoephedrine for a period of 30 days wereclose to normal, while the group treated with pseudoephedrine for a period of (40) days showed shrinkagein the deep layers of the cerebral cortex and hemolysis in many blood vessels, and the meningeal membraneappeared.

Copyrights © 2021