Analysis of The Essential Oil from Lantana camara Leaves and Its Cytotoxic Potential Against T-47D Breast Cancer Cells

Suryati Suryati (Organic Chemistry and Natural Products Laboratory, Department of Chemistry, Universitas Andalas, West Sumatra, Indonesia)
Enda Desriansyah Aziz (Organic Chemistry and Natural Products Laboratory, Department of Chemistry, Universitas Andalas, West Sumatra, Indonesia)
Mai Efdi (Organic Chemistry and Natural Products Laboratory, Department of Chemistry, Universitas Andalas, West Sumatra, Indonesia)
Fatma Sri Wahyuni (Cell Culture Laboratory, Faculty of Pharmacy, Universitas Andalas, West Sumatra, Indonesia)
Dira Hefni (Cell Culture Laboratory, Faculty of Pharmacy, Universitas Andalas, West Sumatra, Indonesia)

Jurnal Riset Kimia
Vol. 12 No. 1 (2021): March

Lantana camara Linn is a family of Verbenaceae which grows wild and is widespread in various both tropical and sub-tropical countries. Isolation essential oil of the L. camara leaves extracted by hydrodistillation and were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). The results of GC-MS analysis show isocaryophyllene (14.39%), ρ-cymene (8.17 %), β-cubebene (7.8 %), α-pinene (7.64 %), and β-elemene (5.51 %) as the main compound. The cytotoxic activity of the isolated essential oil was highly toxic both to Artemia salina shrimp larvae (LC50 15.92 µg/mL) and to breast cancer cells T-47D (IC50 10.67 µM).