Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin

PRAPTIWI PRAPTIWI (Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia)
YULIASRI JAMAL (Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia)
AHMAD FATHONI (Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia)
ARIF NURKANTO (Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia)
ANDRIA AGUSTA (Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia)

Microbiology Indonesia
Vol. 7 No. 4 (2013): November 2013

Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of 32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.