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ARIF NURKANTO
Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin PRAPTIWI PRAPTIWI; YULIASRI JAMAL; AHMAD FATHONI; ARIF NURKANTO; ANDRIA AGUSTA
Microbiology Indonesia Vol. 7 No. 4 (2013): November 2013
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (549.298 KB) | DOI: 10.5454/mi.7.4.4

Abstract

Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of 32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.
Co-Authors AHMAD FATHONI ANDRIA AGUSTA PRAPTIWI PRAPTIWI YULIASRI JAMAL