Patient compliance with medication is one of the treatments for tuberculosis that is of concern. The purpose of this study was to analyze the level of compliance and the relationship of factors to drug use adherence in pulmonary TB patients at Sungai Betung Public Health Center. The method used is analytical observational method by designing a cohort study research. Data collection was carried out retrospectively, namely collecting medical data on pulmonary TB patients and measuring compliance using the Medication Possession Ratio (MPR) method. Data analysis used Chi-Square test with SPSS. The results showed that the majority of patients were male (83.3%), productive age (80%), high school education (33.3%), had a job (83.3%), mileage from home to health services 2km (90%), and underwent treatment for exactly 6 months (63.3%). The patient's compliance rate was 86.7% adherent. Chi-square analysis showed that there was no significant relationship between the level of compliance with age (p=0,557), gender (p=1,000), patients who did not attend school as a comparison between primary and tertiary education (p=1,000; p=0,467; p = 0.125; p=1,000), occupation, distance to service and length of treatment (p=1,000). The conclusion is that there is no relationship between the research variables on drug use adherence.
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