Primary Giant Cell Tumor of Soft Tissue in The Female Breast

Dody Novrial (Department of Anatomical Pathology Faculty of Medicine Universitas Jenderal Soedirman)
Muhammad Yamsun (Department of Surgery Faculty of Medicine Universitas Jenderal Soedirman)

Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan

A giant cell tumor of soft tissue (GCT-ST) is a rare tumor composed of mononuclear and osteoclast-like multinucleated giant cells.  It is a low-grade malignant potential tumor morphologically analog to a giant cell tumor of bone.  The superficial and deep soft tissue of extremities is the most frequent site of this tumor which is cured by complete or radical resection.  GCT-ST as a primary tumor in the female Breast is exceedingly rare.  Presentation of osteoclast-like multinucleated giant cells in the breast tumor has been described in association with the variant of breast carcinoma.  We report a case of primary GCT-ST arising in the female Breast without a relationship with the epithelial component.  To the best of our knowledge, this is the fifth such case report, and only the second one occurred in a female under 50 years.