<![CDATA[The trend of running continues to grow and has even become one of the markers of a modern lifestyle. Many branches of the category of extreme distance and endurance began to be competed in the community. Although it is a simple sport, in the endurance category, there are many aspects that affect the physiological, endurance and performance especially marathon and ultramarathon events. The human body forcefully exposed to different levels of injury risk depending on the distance and time traveled during a match from physical to gene and DNA levels. This study systematically summarizes the literature that discusses biomolecular responses and mechanisms shown by the body during marathon and ultramarathon events as a process of maintaining homeostasis and body defense mechanism.]]>
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