The contribution of Local Government Owned Corporate (BUMD) to Local Own Revenue (PAD) Pati is still low (4.23 percent). Establishing a new medical waste processing company is promising as a new business unit of BUMD since the current company that manages medical waste shows low performance. This study aims to analyze the feasibility of establishing a medical waste treatment business in Pati Regency. In addition, the contribution of the new company to generate PAD also is estimated. The feasibility is assessed based on financial and non-financial aspects. The research method used is a mixed-method with dominant in a quantitative method. The result showed that the establishment of a medical waste treatment company is feasible based on non-financial and financial indicators. Non-financial aspects include market aspect, technical aspect, management and human resources aspects, social and economic aspects, and environmental aspect. Financially, the establishment of this company is feasible acoording to the following indicators: the payback period (3 years 10 months 9 days), Net Present Value (Rp5,245,526,919), and internal rate of return (28.65 percent). The establishment of this company has a good market potential since there is only one waste company as a competitor in Central Java Province. Furthermore, this company offers lower prices compared to its competitor to gain new costumers. Collecting the medical waste on time enables this company to support their customers creating better sanitation. It is estimated that this company will contribute to PAD 0.215 percent by 2023 higher than that of another unit of BUMD.Keywords: non-financial feasiblitiy, financial feasiblitiy, local revenue, medical wasteAbstrakKontribusi laba atas penyertaan modal pada Badan Usaha Milik Daerah (BUMD) terhadap Pendapatan Asli Daerah (PAD) Kabupaten Pati masih rendah (4,23 persen). BUMD tertarik untuk meningkatkan PAD melalui pengelolaan limbah medis karena pengolahan oleh pihak ketiga dianggap kurang optimal. Tujuan penelitian untuk menganalisis kelayakan rencana pendirian usaha pengolahan limbah medis dan menghitung perkiraan kontribusinya terhadap PAD Kabupaten Pati. Metode yang digunakan deskriptif kualitatif dan dianalisis dengan pendekatan kuantitatif. Hasil penelitian menunjukkan bahwa usaha pengolahan limbah medis dinyatakan layak untuk dijalankan, baik dari faktor finansial maupun nonfinansial. Berdasarkan penilaian dari faktor finansial, nilai PP (Payback Period)= 3 tahun 10 bulan 9 hari; NPV (Net Present Value) = Rp5.245.526.919,00; dan IRR (Internal Rate of Return) = 28,65 persen. Faktor nonfinansial meliputi faktor pasar yang terbuka lebar karena hanya ada 1 perusahaan pengolahan limbah medis di Jawa Tengah, harga yang ditawarkan lebih murah Rp2.000,00-Rp7.000,00 per kg dibandingkan pihak ketiga; faktor hukum, izin pengelolaan limbah B3 sudah sesuai prosedur Permen LHK No. 56 Tahun 2015; faktor sosial ekonomi, kenyamanan dan kesehatan masyarakat lebih terjamin karena jadwal pengambilan limbah tepat waktu; faktor lingkungan, mengurangi risiko kontaminasi limbah infeksius; faktor manajemen dan sumber daya manusia, membutuhkan 10 orang tenaga kerja dengan kualifikasi tertentu; serta faktor teknis dan operasional, pemilihan lokasi sudah sesuai prosedur, yaitu di TPA Sukoharjo dengan peralatan utama mesin insinerator sesuai spesifikasi. Diestimasikan laba dari Perusahaan Daerah Aneka Usaha (PDAU) Unit Pengolahan Limbah Medis memberikan kontribusi terhadap PAD Kabupaten Pati pada tahun 2023 sebesar 0,215 persen, lebih tinggi dari pada kontribusi PDAU Unit yang lainnya.Kata kunci: kelayakan nonfinansial, kelayakan finansial, pendapatan asli daerah, limbah medis
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