Aktivitas Antihiperglikemik Fraksi-Fraksi Ekstrak Etanol Daun Genjer (L. flava) pada Tikus Diabetes Nefropati

Yithro Serang (Sekolah Tinggi Ilmu Farmasi Nusaputera Semarang)
Yahya Febrianto (Sekolah Tinggi Ilmu Farmasi Nusaputera Semarang)
Rizky Ardian Hartanto Sawal (Fakultas Farmasi, Sekolah Tinggi Ilmu Farmasi Nusaputera)

JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)
Vol 6, No 2 (2021)

Diabetes mellitus (DM) type 2 can cause complications such as diabetic nephropathy (DN). Genjer leaf (L. flava) can be used as a treatment on the conditions of this study. This research purpose is to know antihyperglikemi activity fractions-fraction ethanol extracts of Africa leaves, repair and regeneration kidney function. This research used 35 white male wistar rats conditioned DM type 2 for 24 days. Rats were divided into 7 groups, group I, group II negative control using STZ-NA 65 mg/kg and 230 mg/kg, group III positive control with glibenklamid 0.45 mg/kg, Group IV ethanol extracts of africa leaves 400 mg/kg, Group V fraction n-heksan 100 mg/kg BB, Group VI fraction of ethyl acetate 100 mg/kg, and Group VII water fraction 100 mg/kg. Data analysis using ANOVA test followed LSD Post Hoc. The results showed that administering fraction-fraction of ethanolic extract of genjer leaf (L. flava) at doses 100 mg/kg BB can lower glucose levels on rat with diabetic nephropathy