Jurnal Farmasi Sains dan Praktis
Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O

ANTIHYPERGLYCEMIC ACTIVITY TEST OF TEAK LEAVES (Tectona grandis L.) ETHANOL EXTRACT IN STREPTOZOTOCIN-INDUCED RATS

Nuralifah Nuralifah (Universitas Halu Oleo, Indonesia)
Parawansah Parawansah (Universitas Halu Oleo, Indonesia)
Nurul Febrina Rahmawati (Universitas Halu Oleo, Indonesia)



Article Info

Publish Date
25 Feb 2022

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. This study aimed to determine the antihyperglycemic activity of ethanol extract of teak (Tectona grandis L.) leaves in streptozotocin-induced rats. A total of 24 rats were grouped into 6 groups, normal control (Kn), positive control (K+), negative control (K-), and the three groups of teak leaf ethanol extract doses of 100, 200, and 300 mg/kg BW (K1, K2, respectively). and K3), mice were treated for 7 days. Before being given treatment, the rats were first induced using streptozotocin at a dose of 40 mg/kg BW. The results showed the administration of ethanol extract of teak (Tectona grandis L) leaves. doses of 100, 200, and 300 mg/kg BW with the positive control (K+) had significant antihyperglycemic activity in male Wistar strain rats based on the Oneway ANOVA test and post hoc LSD test.

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Journal Info

Abbrev

pharmacy

Publisher

Subject

Immunology & microbiology Medicine & Pharmacology Public Health

Description

Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science ...