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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Medula Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Borneo Journal Of Pharmascientech Mattawang: Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Nusantara (JPN) MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Kepada Masyarakat Meambo Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Farmasi Galenika Indonesian Journal of Jamu Journal of Community Engagement in Health MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Parawansah, P

Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Halu Oleo

Author-ID : 1034511

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Uji Aktivitas Antibakteri Sediaan Krim Anti Jerawat Ekstrak Etanol Terpurifikasi Daun Sirih (Piper betle L.) dengan Basis Vanishing Cream Terhadap Propionibacterium acne Nuralifah, N; Armadany, Fery Indradewi; Parawansah, P; Pratiwi, Aulif
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 4, No 2 (2018): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Jerawat merupakan gangguan pada kulit yang ditandai dengan adanya peradangan yang disertai penyumbatan pada saluran kelenjar minyak dalam kulit yang disebabkan oleh bakteri Propionibacterium acne. Salah satu tanaman obat yang dapat dimanfaatkan sebagai obat jerawat adalah daun sirih. Daun sirih diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak dipurifikasi dari klorofilnya dengan metode ekstraksi cair-cair menggunakan pelarut n-heksan. Penelitian ini bertujuan untuk mengetahui efek antibakteri terhadap ekstrak etanol daun sirih terpurifikasi dan sediaan krim dengan basis vanishing cream terhadap bakteri P. acne dengan metode sumuran. Uji stabilitas fisik sediaan krim meliputi pemeriksaan organoleptis, homogenitas, daya sebar, viskositas, pH, dan tipe krim m/a.Â Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirih terpurifikasi dengan konsentrasi 0,5% memiliki daya hambat yang lemah, 1% memiliki daya hambat yang sedang, 1,5% dan 2% memiliki daya hambat pertumbuhan P. acne yang kuat. Konsentrasi ekstrak dalam pembuatan krim antijerawat dengan basis vanishing cream sebesar 0,5% memiliki daya hambat yang lemah, 1% dan 1,5% memiliki daya hambat yang sedang, 2% memiliki daya hambat yang kuat sedangkan kontrol positif (asam retinoat) yang digunakan memiliki daya hambat yang kuat terhadap pertumbuhan P. acne. Krim antijerawat dengan basis vanishing cream dengan konsentrasi ekstrak 2% memiliki aktivitas antibakteri yang paling baik terhadap P. acne.Kata kunci: Anti jerawat, daun sirih, krim m/a, Propionibacterium, antibakteri

Pengaruh Fraksi Ekstrak Buah Pare (Momordica Charantia L.) Terhadap Penurunan Kadar Glukosa Darah Tikus yang Diinduksi Streptozotocin Parawansah Parawansah; Rahmawati Rahmawati; I Putu Sudayasa; Andi Noor Kholidha; Amiruddin Eso; Nuralifah Nuralifah
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25863

Pare adalah tanaman yang sering dimanfaatkan sebagai obat tradisional dalam menyembuhkan berbagai jenis penyakit, diantaranya diabetes mellitus. Kandungan charantine, polypeptide-p, vicine dan antioksidan memiliki potensi menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui aktivitas anti diabetik fraksi ekstrak buah pare dalam menurunkan kadar glukosa darah dan gambaran histopatologi jaringan pankreas tikus yang diinduksi streptozotocin. Penelitian ini menggunakan post test only control group design. Sampel penelitian ini terdiri dari 5 kelompok yaitu kelompok kontrol positif, kelompok kontrol negatif, kelompok fraksi etanol ekstrak buah pare, kelompok fraksi etil asetat ekstrak buah pare, dan kelompok n-heksan ekstrak buah pare. Pengukuran kadar glukosa darah dilakukan pada saat sebelum dilakukannya induksi STZ, setelah induksi STZ, hari ke 4 dan hari ke 7 pemberian fraksi ekstrak buah pare menggunakan glukometer dan spektrofotometer. Pada hari ke 7 dilakukan pembedahan untuk pengambilan sampel darah dan pankreas tikus. Analisis data yang digunakan adalah kruskal-wallis dilanjutkan uji mann-withney. Berdasarkan hasil penelitian, diketahui terdapat perbedaan yang signifikan antara penurunan kadar glukosa darah tikus diabetes mellitus yang diberi fraksi n-heksan ekstrak buah pare dengan kelompok kontrol negatif (p-value<0,05). Sementara itu berdasarkan pemeriksaan histopatologi jaringan pankreas tikus yang diberi fraksi ekstrak buah pare 400 mg/kg diperoleh nilai positif ++. Terdapat aktivitas anti diabetik fraksi ekstrak buah pare dengan presentase tingkat penurunan kadar glukosa darah tikus tertinggi oleh pemberian fraksi n-heksan ekstrak buah pare 400 mg/kg. Terdapat perbedaan gambaran histopatologi jaringan pankreas tikus pada kelompok yang diberi fraksi etanol, fraksi etil asetat, dan fraksi n-heksan terhadap kelompok kontrol positif dan kontrol negatif.

Deteksi Dini Faktor Risiko Penyakit Tidak Menular Pada Masyarakat Desa Andepali Kecamatan Sampara Kabupaten Konawe I Putu Sudayasa; Muhammad Fathur Rahman; Amiruddin Eso; Jamaluddin Jamaluddin; Parawansah Parawansah; La Ode Alifariki; Arimaswti Arimaswati; Andi Noor Kholidah
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 4, No 2 (2020): Agustus
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v4i2.3491

ABSTRAKPenyakit tidak menular (PTM) merupakan penyakit yang tidak ditularkan dan tidak ditransmisikan kepada orang lain dengan bentuk kontak apapun, menyebabkan kematian dan membunuh sekitar 35 juta manusia setiap tahunnya, atau 60% dari seluruh kematian secara global, dengan 80% pervalensi pada negara berkembang. Penyakit tidak menular, khususnya penyakit kardiovaskuler, kanker, penyakit pernapasan kronis, dan diabetes merupakan ancaman utama bagi kesehatan dan perkembangan manusia saat ini. Tujuan pengabdian masyarakat yang terintegrasi kuliah kerja nyata (KKN) Tematik, untuk mendeteksi faktor risiko penyakit tidak menular, pada masyarakat Kecamatan Sampara, Kabupaten Konawe. Metode kegiatan berupa penyuluhan kesehatan, pemeriksaan tekanan darah, kadar kolesterol, gula darah sewaktu dan asam urat. Telah dilakukan skrining dan deteksi dini fator risiko penyakit tidak menular terhadap 67 orang responden, meliputi 14 laki–laki dan 53 perempuan. Pada hasil pemeriksaan tekanan darah, didapatkan jumlah yang mengalami hipertensi 28,35 %, normotensi 67,16, dan hipotensi 4,47 %. Pada pemeriksaan Kolesterol Total, didapatkan kolesterol dalam batas normal 2,38 % dan tinggi 37,31 %. Hasil pemeriksaan gula darah sewaktu (GDS), didapatkan kadar GDS dalam batas normal 85,07 % dan kadar GDS tinggi 14,92 %. Pada pemeriksaan Asam Urat didapatkan dalam batas normal adalah 91,04 % dan tinggi 8,95 %.Kata kunci: faktor risiko; penyakit tidak menular Early Detection of Non-communicable Disease Risk Factors in Andepali Village Community, Sampara District, Konawe RegencyABSTRACTNon-communicable disease (PTM) is a disease that is not transmitted and is not transmitted to others by any form of contact, causing death and killing around 35 million people each year, or 60% of all deaths globally, with 80% prevalence in developing countries. PTM, especially cardiovascular disease, cancer, chronic respiratory diseases, and diabetes are the main threats to human health and development today. The purpose of integrated community service is the Thematic Real Work Study (KKN), to detect risk factors for non-communicable diseases, in the community of Sampara District, Konawe Regency. The method of activity in the form of health education, blood pressure, cholesterol levels, blood sugar and uric acid. Screening and early detection of risk factors for non-communicable diseases have been carried out on 67 respondents, including 14 men and 53 women. On the results of blood pressure examination, it was found that the amount of hypertension was 28.35%, normotension 67.16% and hypotension 4.47%. In the examination of Total Cholesterol, cholesterol was found to be within the normal limit of 2.38% and 37.31% high. Examination results of Blood Sugar (GDS), obtained levels of GDS in the normal range of 85.07% and high GDS levels of 14.92%. In the examination of Gout found in the normal range is 91.04% and high 8.95%.Keywords: gout; blood sugar; cholesterol; non-communicable diseases; blood pressure

Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923 (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923) Nuralifah Nuralifah; Feri Indradewi; Parawansah Parawansah; Satriana Nasrun
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 7, No 1 (2019)
Publisher : Halu Oleo University

Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat

Immunomodulatory Effect of Momordica charantia L. Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages Parawansah Parawansah; Tomy Nurtamin; Sufiah Asri Mulyawati; Nuralifah Nuralifah; Wa Ode Arlina Misnaeni
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.390

BACKGROUND: The purpose of this research is to understand the secondary metabolites of Momordica charantia L. extract, as well as to disclose the potential of M. charantia extract in the phagocytic activity and capacity of peritoneummacrophages.METHODS: Examination of immunomodulatory effect was done by giving M. charantia ethanol extract on 5 treatment groups, given intra-peritoneally to mice daily. Echinacea extract as positive control and double distilled water as negative control were also given. On the 8th day, mice were infected with Staphylococcus epidermidis. After 30 minutes, peritoneum fluid was obtained to observe the activity and capacity of macrophage cells.RESULTS: The results showed significant phagocytic activity (p<0.05) at a concentration of 1,200 ppm compare to the other groups. Meanwhile the macrophage cell capacity was found statistically insignificant (p>0.05). The highest phagocytic activity was the group treated with 1,200 ppm (62%), significantly higher than other groups.CONCLUSION: The secondary metabolite content of M. charantia is alkaloids, flavonoids, tannins, saponins, and triterpenoids. The 1,200 ppm M. charantia ethanol extract is potential in inducing phagocytic activity and capacity. These results indicate that the M. charantia can be suggested as a natural immunomodulator.KEYWORDS: pare fruit, Momordica charantia L., phagocytosis, macrophage, immunomodulator

Momordica charantia L. Fruit Fractions inhibit Malondialdehyde Level and Regenerate Hepatic Damage of Hyperglycemic Rats Parawansah Parawansah; I Putu Sudayasa; Andi Noor Kholidha Syarifin; Amirudin Eso; Nuralifah Nuralifah; Wa Ode Siti Rahayu Fathanah; Ferry Sandra
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.963

BACKGROUND: Chronic hyperglycemia causes an increase of free radical production and in longterm, the hyperglycemia increases oxidative stress. Among medicinal plants, Momordica charantia L. fruit has been known to overcome hyperglycemia. However, role of M. charantia L. fruit on oxidative stress is not well understood. Therefore, current study was conducted to investigate the effect of M. charantia L. fruit extract on malondialdehyde (MDA) level and hepatic damage in hyperglicemic rat model.METHODS: Twenty five white rats (Rattus novergicus) were induced with Streptozotocin (STZ) and treated with/without glibenclamide, sodium carboxymethyl cellulose (Na-CMC), or M. charantia L. fruit ethanol/ethyl acetate/ n-hexane fraction. After the treatment, rat’s livers were collected and separated for histopathological examination and MDA analysis.RESULTS: The MDA level average of rats before the STZ induction was 1.37 μg/mL. MDA level average was markedly increased (23.85 μg/mL) in rats induced with STZ and treated with Na-CMC merely. The MDA level average of STZ-induced glibenclamide-treated rats was 3.12 μg/mL. Meanwhile, the MDA level averages of STZ-induced M. charantia L. fruit ethanol, ethyl acetate and n-hexane fractions-treated rats were 14.95, 8.98 and 5.37 μg/mL, respectively. The histopathology results of this study showed that adipocytes, dilated sinusoids and central vein thickening were mostly observed in STZ-induced Na-CMC-treated rats. Meanwhile, the STZ-induced ethanol/ethyl acetate/n-hexane fraction-treated rats did not exhibitthose expressions.CONCLUSION: M. charantia L. fruit fractions inhibit the MDA level average in liver tissue and regenerate hepatic damage of STZ-induced rats, especially the n-hexane fraction which could be a potential hepatic antioxidant and regenerative agent.KEYWORDS: Momordica charantia L., malondialdehyde, oxidative stress, hyperglycemia, diabetes mellitus

Inhibition of Xanthine Oxidase Activity by Ethanolic Extract of Piperomia pellucida L., Acacypha indica L. and Momordica charantia L. Parawansah Parawansah; Nuralifah Nuralifah; Gemini Alam; Rosdiana Natzir
The Indonesian Biomedical Journal Vol 8, No 3 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i3.194

BACKGROUND: Uric acid is a final result of purine catabolism, the enzymatic reactions in the body cells from amino acids or ribonucleotide dinucleotide. Peperomia pellucida L. (P. pellucida), Acalypha indica L. (A. indica) and Momordica charantia L. (M. charantia) are plants which have efficacy to reduce levels of uric acid excess. The aim of this research is to find out the effect of ethanol extract of P. pellucida, A. indica and M. charantia in preventing the formation of uric acid excess by inhibiting the action of the enzyme xanthine oxidase and comparing the inhibition activity of xanthine oxidase on treatments.METHODS: The study design is experimental and conducted using the enzyme xanthine oxidase, xanthine (substrate), pH 7.5 phosphate buffer, samples (P. pellucida, A. indica and M. charantia ethanol extracts) and HCL as reaction breaker. Inhibition of xanthine oxidase was determined enzymatically and unreacted xanthine was measured by UV spectrophotometer at 290 nm. The data were expressed as percent inhibition and the inhibitory concentration (IC)50 were determined using linear regresion of inhibition activity vs. concentration.RESULTS: The IC50 of P. pellucida, A. indica and M. charantia ethanol extracts in inhibiting xanthine oxidase were 19.5 ppm, 77.6 ppm and 17.8 ppm, respectively. IC50 of allopurinol was 1.99 μg/ml, and negative control (combination of enzyme and substrate) has absorbance value of 0.75026.CONCLUSION: Ethanol extract of M. charantia showed the most potent inhibition toward xanthine oxidase compared to the other two extracts.KEYWORDS: xanthine oxidase, Peperomia pellucida L., Acalypha indica L., Momordica charantia L.

Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar Nuralifah Nuralifah; Wahyuni Wahyuni; Parawansah Parawansah; Ulan Dwi Shintia
Journal Syifa Sciences and Clinical Research Vol 2, No 1 (2020): Volume 2 Edisi 1 2020
Publisher : State University of Gorontalo

Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.

FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α) Parawansah Parawansah; Nuralifah Nuralifah; Yulfa Yulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13484

Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.

Histopatologi Organ Pankreas Tikus DM tipe 2 yang diberi Ekstrak Etanol Daun Gedi Merah (Abelmoscus manihot L. Medik) Nuralifah Nuralifah; La Ode Muhammad Fitrawan; Parawansah Parawansah; Mesrawati Trisetya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13566

Gedi Merah leaf (Abelmoschus manihot L.Medik) is a tropical plant used by the community as a traditional medicine to reduce cholesterol, hypertension, and antidiabetic levels. Diabetes mellitus is a disorder of carbohydrate, protein, and fat metabolism due to a lack of the hormone insulin so that glucose in the blood increases which is characterized by changes in the histopathological structure of the pancreatic islets of Langerhans. The purpose of this study was to see the histopathological description of the pancreas in male white rats (Rattus norvegicus) Wistar strain model of type II diabetes mellitus by administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik). Modeling of diabetes mellitus in experimental animals was carried out by administering a high-fat diet and intraperitoneal induction of streptozotocin 30 mg/kg. After modeling, male rats were grouped into 6 treatment groups, namely a normal control group, a positive control group, a negative control group, and a group that was given the ethanol extract of red gedi leaves at a dose of 75 mg/kg BW, 150 mg/kg BW 300 mg/kg BW. The results of the histopathological examination of the pancreas and the number of endocrine cells showed that the ethanolic extract of red gedi leaves (Abelmoschus manihot L.Medik) was effective in repairing pancreatic cells and regenerating endocrine cells in the islets of langerhans.

Co-Authors ,, Suryani Abd Rafid Adryan Fristiohady Agung Wibawa Mahatva Yodha Alda Rizma Ali, Agussalim Alifariki, La Ode Alya Zuhriyah Amaliah Amaliah Amirudin Eso Amirudin Esso Ance Triana Andi Noor Kholidah Anisa Fauzia Asri Anwar, Irvan Arfan Arfan Arfan Arfan Arimaswti Arimaswati Armadany, Fery Indradewi Ashaeryanto Asna Ramadani Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Aulia Sakinah Diah Ayi Tri Hapsari Badia, Esti Dewi Rahmawati Rufia Dian Munasari Solo Dias Tama Diasty Nuraisya Dita Rizqyah Djusiana Eka Cessaria Elhamayasari Elhamayasari Elvantri Yani Emma Haerunnita Eso, Amiruddin Fadhliyah Malik Fadhliyah Malik Fadilah Fadilah Fatimardiyach Rahmi Feri Indradewi Ferry Sandra Fitrawan, La Ode Muhammad Gemini Alam Ghina Salsabila Awandhaputri Hasnawati Hasnawati Hutamy Viranda Rahman I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa Indah Latif Indar Prasti Indriyati Indriyati Irmawati Irmawati Jamaluddin Jamaluddin Juminten Saimin Kasmawati, Henny Kiki Murni La Ode Alifariki La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Rangki Lidya Agriningsih Haruna Loly Subhiaty Idrus Lukman La Basy Mesrawati Trisetya Molifa Dalis Mubarak Mubarak Muh Aidil Adha Muhammad Fathur Rahman Muhammad Fathur Rahman Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Junaid Azis Mulyawati, Sufiah Asri Nada Shofa Nadiya Mutmainnah Nasrudin Nasrudin Nidya Aftira Nining Yulianti Nining Yulianti Nirwati Rusli Nita Trinovitasari Nita Trinovitasari Nur Illiyyin Akib Nur Misa Nuralifah Nuralifah, Nuralifah Nurramadhani A. Sida Nurramadhani Asida Nurul Afifah Yusran Nurul Febrina Rahmawati Nuzul Aulia Fajarwati B Pratiwi, Aulif Puteri Febriyanthi Rachman Rachma Malina Radja Al Fath Widya Iswara Rahimah Nurfadilah Dahlan Rahmawati Rahmawati Rahmawati Rahmawati Rahmawati Rathapon Asasutjarit Rifa’atul Mahmudah Risma Ritha Hastria Rosdiana Natzir Ruslin S. Sukurni Sabarudin Sabarudin Sahidin Sahidin Saida Saida Satriana Nasrun Selvi Selvi Selvy Aulia Sernita Sherly Intan Ardani Sitti Humairah Suchi Febriani Sulastrianah Sulastrianah, Sulastrianah Syarifin, Andi Noor Kholidha Tien Tien Tomy Nurtamin Tridamayanti Fataraing Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Chesaria F.A Wa Ode Salma Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Zubaydah Wa Ode Yentri Putia Ningtiyas Darmin Wahyuni Wahyuni Wandarsih Juniarti Akbar Waode Shima Indisia Yamin Yamin, Y Yulfa Yulfa Yuliani Uzuni

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