This study aims to compare the effectiveness of pharmacological therapy with pharmacological therapy accompanied by spiritual mindfulness based on breathing exercises on anxiety levels and blood glucose levels in type 2 DM patients. This study is a quasi-experimental study using a pretest-posttest design with a control group design. The results showed that there were differences in the level of anxiety of patients in the control group and the experimental group with a P-Value of 0.035 <0.05, and there were differences in the blood sugar levels of patients in the control group and the experimental group with a P-Value of 0.002 <0.05. In conclusion, pharmacological therapy interventions accompanied by spiritual mindfulness based on breathing exercises were proven effective in reducing anxiety and blood sugar levels in type 2 DM patients. Keywords: Type 2 DM, Blood Glucose, Anxiety, Mindfulness
                        
                        
                        
                        
                            
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