Efektivitas multi drug therapy pada transmisi morbus hansen transplasental

Dhelya Widasmara (Departemen/SMF Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia)
Santosa Basuki (Departemen/SMF Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia)
Dea Florensia (Departemen/SMF Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia)
Ade Setyagraha (Departemen/SMF Obstetri Ginekologi, Fakultas Kedokteran Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia)
Nugrahanti Prasetyorini (Departemen/SMF Obstetri Ginekologi, Fakultas Kedokteran Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia)

ISM (Intisari Sains Medis) : Jurnal Kedokteran
Vol. 11 No. 2 (2020): (Available online: 1 August 2020)

Introduction: The evidence of transplancental transmission of Morbus Hansen (MH) in animal models is a challenge for MH treatment in pregnancy because it brings anxiety for patients and their fetuses. Case: A 31-year-old pregnant woman, first trimester, came with complaints of reddish numbness rash on her hands since 2 years ago. Dermatological examination showed erythematous plaque, multiple, well-defined, irregular borders with hypoaesthesia. There were right and left ulnar nerve enlargement. Acid Fast Bacteria (AFB) from ear lobes and lesion revealed Bacterial Index +2 and Morphological Index 10%. Histopathological examination showed gren zone which indicate MH type BL. Patient was diagnosed with MH Multi Basiler (MB) on G3P2002Ab000 and given MDT MHMB. Postpartum IgM and IgG anti-PGL-1 examination of cord blood and infant blood, also PCR examination of cord blood and amnion showed negative results. Histopathological examination found no AFB on the umbilical cord and placenta. Conclusion: MDT is effective in preventing transplacental transmission of MH from mother to fetus.