Infection and Colorectal Neoplasm

Gontar Alamsyah Siregar (Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara/Adam Malik General Hospital Medan, Indonesia)
Sahat Halim (Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara/ Adam Malik General Hospital, Medan, Indonesia)
Ricky Rivalino Sitepu (Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara/ Adam Malik General Hospital, Medan, Indonesia)

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Vol 16, No 1 (2015): VOLUME 16, NUMBER 1, April 2015

Colorectal cancer is a major cause of cancer-related morbidity and mortality. Colorectal cancer is the third most common malignancy and the 4th most common cause of cancer mortality worldwide. A number of infectious agents are considered to be cancer risk factors due to the hypothesis-generating and supportive evidence accumulated to date. It has been estimated that one fifth of all cancer is caused by some infectious agent(s). Infections from certain bacteria, such as Helicobacter pylori (H. pylori), Streptococcus bovis (S. Bovis), viruses, such as human papillomavirus (HPV), human cytomegalovirus (HCMV), and parasites may increase the risk of colorectal cancer. More studies are needed to learn the association of infectious agents with the incidence of colorectal cancer.Keywords: colorectal cancer, infectious agents, malignancy, neoplasms