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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 771 Documents
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Candidiasis in Malignancy Diany N Taher; Ari Fahrial Syam; Murdani Abdullah; Jumhana Atmakusuma; Khie Chen
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 1, April 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/71200628-31

Abstract

Esophageal candidiasis presents with a range of clinical findings and is rarely found among immunocompetent patient without predisposing factors. Between 20-50% of patient may be asymptomatic. One of predisposing factor of candidiasis is immunocompromised condition due to malignancy. Dysphagia is the most frequently presented feature of esophageal carcinoma. We demonstrated a case of esophageal candidiasis as one of early clinical presentation in patient with esophageal carcinoma. Keywords: esophageal candidiasis, esophageal carcinoma
Comparison of Helicobacter pylori Detection Using Immunohistochemistry and Giemsa and Its Association with Morphological Changes in Active Chronic Gastritis Wildawati Nurdin; Ening Krisnuhoni; Kusmardi Kusmardi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.502 KB) | DOI: 10.24871/171201621-27

Abstract

Background: Gastritis is an inflammation of the gastric mucosa as a response to infection or irritation of the gaster. The most common aetiology of chronic gastritis is Helicobacter pylori (H. pylori) infection. Presence of H. pylori is associated with the occurrence of inflammation, atrophy, and intestinal metaplasia. In terms of morphology, H. pylori is known in 2 forms, which are rod-shaped and coccoid-shaped. Coccoid-shaped bacteria are difficult to detect using Giemsa staining. Therefore, immunohistochemistry staining of H. pylori and evaluation of the sensitivity of coccoid-shaped of H. pylori are needed.Method: Cross-sectional study on 90 biopsy tissues of chronic gastritis patients in year 2015 and 2014, which included 30 Giemsa cases with positive H. pylori, 30 cases of active chronic gastritis with negative H. pylori but coccoid-shaped was found, and 30 non-active chronic gastritis, were subsequently stained with immunohistochemistry staining of H. pylori.Results: Expression of coccoid-shaped H. pylori in active chronic gastritis was significantly different (p 0.05) in immunohistochemistry staining. There was a significant difference between active chronic gastritis with positive H. pylori and negative H. pylori in immunohistochemistry staining with degree of inflammation. Sensitivity and specificity test between Giemsa and immunohistochemistry staining showed sensitivity of 65% and specificity of 100%.Conclusion: Immunohistochemistry staining in active chronic gastritis was more sensitive compared to Giemsa staining in detecting H. pylori, particularly the coccoid-shaped bacteria.
The Role of Wisteria Floribunda (M2BPGi) Serum Level for Diagnosing Liver Fibrosis in Hepatitis B Patient: An Evidence Based Case Report Yosafat Lambang Prasetyadi; Agnes Elsha Maria Simbolon; Anggi Anggelina Permatasari; Dela Ryana Swaraghani; Shafira Chairunisa; Juferdy Kurniawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 2 (2019): VOLUME 20, NUMBER 2, August 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (479.886 KB) | DOI: 10.24871/2022019129-133

Abstract

Aim: To assess M2BPGi serum performance compared to liver biopsy in diagnosisng liver fibrosisMethod: Literature search using Pubmed®, Ebsco®, ProQuest®, Scopus®, Clinical Key databases, and the Cochrane Library® yield four relevant and full-text articles. The four articles were critically appraised for its validity, importance, and applicability.Results: Sensitivity and specificity in all four studies showed that M2BPGi serum was inadequate to ruling in and ruling out the diagnosis of liver fibrosis in chronic hepatitis B patients. The difference in M2BPGi cut-off value to determine the stage of fibrosis in each study makes this value cannot be used as an accurate standard to determine the advanced stage (F≥3) of liver fibrosis. On the other hand, M2BPGi serum combined with other tests are known to improve the diagnostic accuracy.Conclusion: MBP2Gi serum cannot be used as a diagnostic modality for detecting liver fibrosis in chronic hepatitis B patients.
Current Treatment of Gastroesophageal-Esophagitis Reflux Disease Chudahman Manan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 2, NUMBER 3, December 2001
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/23200131-34

Abstract

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Age and Alarm Symptoms Predict Upper Gastrointestinal Malignancy among Patients with Dyspepsia Hendra Koncoro; I Ketut Mariadi; Gde Somayana; IGA Suryadarma; Nyoman Purwadi; IDN Wibawa
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 2, August 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.743 KB) | DOI: 10.24871/142201373-80

Abstract

Background: Upper gastrointestinal (UGI) malignancy is one of the major causes of cancer related death. Endoscopy in dyspeptic patients above 45 years, or those with alarm symptoms may detect this condition. There were only limited data in Indonesia about age and alarm symptoms to predict UGI malignancy. This study was aimed to determine the prevalence of UGI malignancy among dyspepsia patients and to develop a simple clinical prediction model.Method: A cross-sectional study to 390 patients with dyspepsia underwent endoscopy in Endoscopy Unit of Sanglah Hospital Denpasar between July 2012 and June 2013 was conducted. Demography and alarm symptoms were documented. Chi-square and logistic regression test analysis were conducted to analyze variables associated with UGI malignancy.Results: Twenty (5.13%) of 390 patients with dyspepsia had UGI malignancy. Of the 20 patients, 65% were gastric cancer and 30% were esophageal cancer. The mean age was 59 ± 12 years. Variables associated with UGI malignancy were weight loss (OR = 8.2), dysphagia (OR = 6.2), age 45 years old (OR = 5.6), gastrointestinal bleeding (OR = 5.5), persistent vomiting (OR = 5.4), and anemia (OR = 4.9). Using a simplified rule of age 45 years and the presence of any alarm symptom, sensitivity was 85% and specificity was 67.57%.Conclusions: UGI malignancy was found in 5.13% of patients with dyspepsia who underwent endoscopy. Simple clinical prediction model states that age above 45 years and alarm symptoms may be used as a screening tool to predict UGI malignancy.Keywords: dyspepsia, alarm symptoms, upper GI malignancy, clinical prediction model
Upper Gastrointestinal Endoscopy and Histopathology Appearance in Indonesian Children with Recurrent Epigastric Pain F M Susanto; Badriul Hegar; Agus Firmansyah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 3, December 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/83200767-70

Abstract

Background: Recurrent Epigastric Pain (REP) is a clinical symptom frequently found in children. Data of the correlation between duration of illness, frequency of illness, associated symptoms of REP and the abnormality of endoscopic and histopathologic appearance are still limited, especially in Indonesia. The role of Helicobacter pylori (H. pylori) infection in causing organic abnormalities of the gastrointestinal tract (GIT) is also still controversial. Aim:To know the endoscopic and histopathologic appearance and the prevalence of Helicobacter pylori infection, 169 children with REP was performed for endoscopic and histopathologic examination in Department of Pediatric, Cipto Mangunkusumo hospital. Result:Endoscopic and histopathologic abnormalities were found significantly in children who suffered from REP more than 9 months and more than 6 times during 3 months of period. Conclusion: Endoscopic and histopathologic examinations should be considered in children with REP. Keywords: recurrent abdominal pain, epigastric pain, Helicobacter pylori, endoscopy and histopathology
Chemopotential Features of Annona muricata Leaves for Colorectal Neoplasm Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.422 KB) | DOI: 10.24871/1732016153-154

Abstract

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The Risk Factors of Pancreatic Cancer Patients in Dr. Cipto Mangunkusumo National Hospital, Jakarta During 2014-2019 Kaka Renaldi; Teddy Septianto; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 2 (2020): VOLUME 21, NUMBER 2, August 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.035 KB) | DOI: 10.24871/2122020120-125

Abstract

Background: Pancreatic cancer is a very rare cancer with age-adjusted rates ranging from about 5 to 10 new cases per 100,000 persons per year. It has one of the worst prognoses of any type of cancer, with a 5-year survival rate of only 4.6%. Several risk factors have been identified, including older age, smoking, familial history of pancreatic cancer, obesity, chronic pancreatitis, diabetes mellitus, and alcohol consumption.Method: This was a descriptive study describing the risk factors of patients who were diagnosed with pancreatic cancer in the period between 1 January 2014 – 1 January 2019 at the Cipto Mangunkusumo National Referral Hospital (RSCM) Jakarta. Data were obtained from the medical records and Endoscopic Retrograde Cholangiopancreatography (ERCP) database from the RSCM Gastrointestinal Endoscopy Center.Results: From January 2014 to January 2019 there were 123 patients with newly diagnosed pancreatic cancer in RSCM. The mean age was 52 years old. The incidence of pancreatic cancer is more common in men (53%) than women (47%). The most common risk factor identified is smoking which was found in 29% of patients, followed by obesity at 27.9% and a history of diabetes mellitus at 19.5%. Risk factors with a fairly low prevalence include alcohol consumption at 9.7% and chronic pancreatitis at 2.4%. No family history of pancreatic cancer is identified in any subject.Conclusion: Smoking, obesity, and diabetes mellitus are common risk factors in pancreatic cancer patients. In contrast, chronic pancreatitis, alcohol consumption, and family history of pancreatic cancer are less commonly identified in patients.
Management of Upper Gastrointestinal Bleeding due to NSAID Gastropathy that is Unresponsive to Ranitidine Lusy Erawati; Sayid Ridho; Ginova Nainggolan; Ari Fahrial Syam; Chudahman Manan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, ISSUE 2, August 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/42200359-63

Abstract

Non steroidal anti-inflammatory drugs (NSAIDS) are now commonly used in clinical practice. On the other hands, this drug could result severe complication such as bleeding and perforation. In such condition, proton pump inhibitor can be used to stop bleeding than H2 antagonists. We reported one cases of upper gastrointestinal bleeding due to NSAID gastropathy that was unresponsive to Ranitidine. The treatment was suitable to proton pump inhibitor that could overcome upper gastrointestinal bleeding.
The Role of Various Laboratory Parameters and Imaging Associated with Obstructive Jaundice in Cholangiocarcinoma Sri Suryo Adiyanti; Rustadi Sosrosumihardjo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 1 (2014): VOLUME 15, NUMBER 1, April 2014
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4782.815 KB) | DOI: 10.24871/151201457-62

Abstract

Cholangiocarcinoma is the second most common primary liver malignancy with a global increase ofincidence and mortality. The mean age at presentation is 50 years. Patients with cholangiocarcinoma usuallywill have symptoms of obstructive jaundice followed with supporting laboratory and imaging findings. Thepredominant clinical feature of extrahepatic cholangiocarcinoma is biliary obstruction resulting in jaundice; while intrahepatic cholangiocarcinoma causes symptoms of intrahepatic mass including abdominal pain in right upper quadrant and other tumor-related symptoms such as cachexia and malaise. The diagnosis and stagingof cholangiocarcinoma require multidisciplinary approaches including laboratory, radiological, endoscopicapproaches and analysis on pathology. This case report describes a patient with a cholangiocarcinoma based on results of endoscopic retrogradecholangiopancreatography (ERCP) imaging. In addition to a diagnosis tool, ERCP can also be a therapeuticmodality for placing stent to reduce symptoms of cholestasis. There were supporting laboratory findings suchas increased bilirubin level, alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT) levels as wellas increased level of tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9and cytological examination.Keywords: cholangiocarcinoma, jaundice, obstructive, ERCP ABSTRAKKolangiokarsinoma merupakan keganasan hati primer kedua yang paling umum, dimana insiden danmortalitasnya meningkat secara global. Usia rata-rata timbulnya gejala adalah 50 tahun. Pasien dengankolangiokarsinoma pada umumnya mengalami gejala ikterus obstruktif disertai dengan hasil laboratoriumdan pencitraan yang mendukung. Gambaran klinis yang predominan dari kolangiokarsinoma ekstrahepatik adalah obstruksi bilier yang menyebabkan ikterus, sedangkan kolangiokarsinoma intrahepatik menimbulkan gejala adanya massa intrahepatik yang menyebabkan nyeri kuadran kanan atas abdominal dan gejala terkaittumor lainnya yaitu kakeksia dan malaise. Diagnosis dan staging kolangiokarsinoma memerlukan pendekatanmultidisipliner antara lain laboratorium, radiologis, endoskopi dan analisis patologi.Pada kasus berikut ini seorang pasien didiagnosa kolangiokarsinoma yang ditegakkan berdasarkan pencitraanendoscopic retrograde cholangiopancreatography (ERCP). Selain untuk diagnosis, ERCP menjadi modalitasterapi dengan dilakukan pemasangan stent untuk mengurangi gejala kolestasis. Pemeriksaan laboratoriumyang mendukung antara lain peningkatan bilirubin, alkalin fosfat dan gamma glutamil transferase (GGT),peningkatan penanda tumor seperti carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, dan pemeriksaan sitologi.Kata kunci: kolangiokarsinoma, ikterus, obstruktif, ERCP

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