Signet-Ring Cell Carcinoma of the Ampulla of Vater

Lianda Siregar (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Imelda M Loho (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Agus Sudiro Waspodo (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Dwi Sri Rejeki (Department of Anatomical Pathology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Fajar Firsyada (Department of Surgery, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Rahmanandika Swadari (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Getty Inash Nandika (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)
Muhammad Iqbal Siregar (Department of Gastroenterology and Hepatology, Dharmais National Cancer Center Hospital, Jakarta, Indonesia)

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Vol 19, No 2 (2018): VOLUME 19, NUMBER 2, August 2018

Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is a very rare case and only 28 cases have beed reported in the English literature. Herein, we report a 59-year-old woman with SRCC of the ampulla of Vater. She developed symptoms of obstructive jaundice at early stage of disease and underwent pylorus-preserving Whipple procedure as definitive treatment. Histopathology examination showed numerous tumor cells with intracytoplasmic mucin and eccentric nuclei. Her tumor has already invaded the serosa of duodenum, but no infiltration to the stomach, pancreas, and lymphovascular structure. Her surgical margins and regional lymph nodes were free of tumor. She was diagnosed with T2N0M0 (stage IB) SRCC of the ampulla of Vater. No adjuvant treatment was given and she has been doing well for five months after surgery.