<![CDATA[Insulin resistance in Type 2 Diabetes Mellitus (T2DM) is indicated with high fasting blood glucose level, fasting insulin and HOMA-IR. The long-time consume of diabetes drugs would bring harm. Rosella can be used as a complementary drug to improve insulin resistance and prevent T2DM complications.This study seeks the effect of consuming Rosella on fasting blood glucose, fasting insulin and HOMA-IR in T2DM patients.The study design used double-blinded & placebo-controlled randomized clinical trial with intervention (placebo and Rosella) for 8 weeks. The sample consisted of 52 T2DM outpatients at Health Office Yogyakarta City. Measurement of fasting blood glucose was conducted through GOD-PAP method, fasting insulin was measured by MEIA, HOMA-IR was calculated with HOMA Calculator 2.2.3 Version. Analysis of the influence of Rosella on fasting blood glucose, fasting insulin and HOMA-IR level in one group were tested with the Wilcoxon Signed Test and the effect between groups were tested through Mann Whitney with a significance level of 95%.Rosella consumption can reduce fasting blood glucose, fasting insulin and HOMA-IR levels. There was a significant effect of Rosella administration on decreasing fasting blood glucose level in T2DM patients (p=0.001) but there were no significant effect on decreasing fasting plasma insulin level and HOMA-IR levels (p=0.932 and p=0.368). Rosella can improve insulin resistance by reducing fasting blood glucose levels, fasting insulin levels and HOMA-IR values.]]>
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