Kadar Plasma 25-Hydroxyvitamin-D (25-OHD) pada Pasien Age-related Macular Degeneration (AMD) Stadium Akhir di Yogyakarta: Studi Korelasi

Supanji Supanji (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Dewi Fathin Romdhoniyyah (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Ayudha Bahana Ilham Perdamaian (Age-related Macular Degeneration (AMD) Research Group, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Anindita Dianratri (Age-related Macular Degeneration (AMD) Research Group, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Muhammad Bayu Sasongko (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Angela Nurini Agni (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Tri Wahyu Widayanti (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Firman Setya Wardhana (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Dian Caturini Sulistyaningrum (Department of Health and Nutrition, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Mohammad Eko Prayogo (Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia)
Masashi Kawaichi (Functional Genomic and Medicine Laboratory, Nara Institute of Science and Technology (NAIST), Nara, Japan)
Chio Oka (Functional Genomic and Medicine Laboratory, Nara Institute of Science and Technology (NAIST), Nara, Japan)

JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI, Vol 13, No 3, (2022)

Background: Age-related Macular Degeneration (AMD) is a degenerative disease caused by multiple factors, including inflammation. This condition may lead to irreversible macular damage. Vitamin D has anti-inflammatory and immune-modulating qualities, therefore, is expected to protect against the development of AMD.Objective: This study aimed to evaluate the correlation between plasma 25-hydroxyvitamin D (plasma 25-OHD) levels and neovascular Age-Related Macular Degeneration (nAMD).Methods: This was a case-control study involving AMD and control subjects. All subjects underwent a standardized eye examination to check for eligibility by a retinal specialist. Blood samples were drawn for analysis using a DRG Elisa Kit to determine the plasma 25-OHD (Total). Plasma 25-OHD levels were categorized into deficiency (<12 ng/mL), insufficiency (12 - <20 ng/mL), adequate (20 – 50 ng/mL), and high (>50 ng/mL).Results: Total subjects were 39, which consisted of 20 AMD subjects and 19 controls. There were 17 male subjects (43.6%) and 22 female subjects (56.4%). The mean age for the case and control group was 69.35±7.04 and 68.26±6.83, respectively (p=0.612). Those in their 70s dominated the age distribution with a percentage of 56.41% of all participants. The mean plasma 25-OHD in the case group was 32.30±17.10 ng/mL, while the control group was 50.63±11.95 ng/mL (p=0.066). There was no significant association between AMD and plasma 25-OHD levels in all groups (p>0.05).Conclusion: Plasma 25-OHD levels did not correlate positively with nAMD in our study population.