Jurnal Farmasi Sains dan Komunitas
Vol 19, No 2 (2022)

The Epigenetic Impact of Vegetables-Derived Dietary Compounds in Neurodegenerative Conditions : A Review

Vania Amanda Samor (Master in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta 55281)
Yurida Ni'ma Annisa (Master in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta 55281)
Muthi Ikawati (Macromolecular Engineering Laboratory, Department of Pharmacy Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281)
Nunung Yuniarti (Pharmacology and Toxicology Laboratory, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281)



Article Info

Publish Date
30 Nov 2022

Abstract

Dietary compounds from the foods we eat on a daily basis offer several benefits; they help prevent disease and preserve health. The epigenetic advantages of the vegetables we eat every day are one of the benefits that have not been well-reported. Epigenetic pathways involving histone modification, DNA methylation, and alterations caused by miRNAs are extensively engaged in signal transmission, cell development, and death in various disease states, including brain cells. Through this narrative review collected from multiple studies available on reputable online databases until March 2022 shows the epigenetic advantages of various vegetables' content such as gallic acid, quercetin, kaempferol, apigenin, luteolin, resveratrol, genistein, sulforaphane, and diallyl disulfide in neurodegenerative conditions are summarized. However, in-depth investigations are still required to clarify these epigenetic mechanisms before these compounds are ready to be used in the future, as several studies still provide contradictory results

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Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...