Varieties of sea urchins can be found in the Indonesian`s ocean. Empirically, Indonesian citizens have been used it as food and medicine. Research about sea urchins had been conducted to give scientific evidence for further usage.  This article will provide information about biological structure, nutritional value, and biological activities of sea urchins. The habitat and morphological structure will be described. Nutritional compound that had been identified from sea urchin are carbohydrate, essential amino acid, essential fatty acid, vitamin, carotenoid, mineral, and albumin. Sea urchin also contained some bioactive compound such as polysaccharides, sulphated polysaccharide, and fucoidan. Traditionally, sea urchins have been used as antiinflammation, antimicrobial, antioxidant, anticancer, anti-fatigue, antidiabetic, and anti-allergic agent. Several biological activities that have been proved scientifically are antioxidant, anticancer, antimicrobial, antiinflammation and anti-haemolytic activity either from the extract or bioactive compound. Therefore it can be concluded that sea urchin have numerous potential bioactive compounds that can be developed into pharmaceutical  and/or nutraceutical product. Keywords: Sea urchin, morphology, nutrition, bioactivities, bioactive compound.
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