<![CDATA[Rheumatoid Arthritis (RA) is an autoimmune disease characterized by inflammation of the joints. The selection of corticosteroids with broad indications is used as an adjunct therapy because of its anti-inflammatory activity and immune suppression. The research aimed to determine the efficacy and safety profile of corticosteroids in rheumatoid arthritis patients. The method used was a literature review with a narrative review design based on inclusion and exclusion criteria through the PubMed and Google Scholar databases. The results showed that the Prednisone group with varying doses of 5 mg; 6.25 mg; 10 mg gave better efficacy than the placebo group or Methotrexate monotherapy against disease activity with the DAS28 parameter. Prednisone safety was observed from the side effects, hypertension; hyperglycemia and adverse events, headache; reported diarrhea. The review show that the use of Prednisone tab 10 mg/day provided the best efficacy in the first 3 months (p<0.001) with the DAS28 parameter which achieved the greatest clinical remission. The side effects of Prednisone could not be concluded between the effect of dose and the level of drug safety.]]>
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