<![CDATA[ AbstrakDaun nangka (Artocarpus heterophyllus Lamk.) dan daun sirsak (Annona muricata L.) merupakan beberapa bahan alam yang secara empiris digunakan untuk penanganan Diabetes Mellitus. Penelitian ini dilakukan untuk mengetahui aktivitas antihiperglikemia ekstrak tunggal dan kombinasi daun nangka dan daun sirsak. Aktivitas antihiperglikemia diuji dengan metode toleransi glukosa pada mencit jantan galur Swiss Webster yang diinduksi glukosa 195 mg/20g BB. Penelitian terdiri dari bbrp kelompok yaitu kelompok kontrol positif, ekstrak daun nangka 7 mg/20 g BB, ekstrak daun sirsak 3,5 mg/20 g BB, kombinasi ekstrak daun nangka dan daun sirsak (1+1), dan kombinasi (½+½) serta pembanding metformin 1,3 mg/20 g BB. Kadar glukosa darah diukur setiap 30 menit selama 2 jam setelah pemberian glukosa menggunakan alat gukometer. Data kadar glukosa darah dan persen penurunannya dianalisa dengan ANAVA dan uji lanjut Tukey HSD. Dari hasil penelitian dapat disimpulkan bahwa ekstrak daun sirsak dosis 3,5 mg/20 g BB mencit memiliki aktivitas antihiperglikemia yang lebih baik dibandingkan ekstrak daun nangka dan kombinasi ekstrak daun nangka dan daun sirsak. Kata kunci: daun nangka, Artocarpus heterophyllus Lamk., daun sirsak, Annona muricata L., aktivitas antihiperglikemia AbstractJackfruit leaf (Artocarpus heterophyllus Lamk.) and soursop leaf (Annona muricata L.) are some natural materials which empirically used for the treatment of Diabetes Mellitus. This study was aimed to determine antihyperglycemic activity of single and combination extract of jackfruit leaf and soursop leaf. Antihyperglycemic activity had been examined by glucose tolerance method on Swiss Webster male mice that induced by glucose 195 mg/20g BW. This study consist of 6 groups, those are positive control group, jackfruit leaf extract 7 mg/20 g BW, soursop leaf extract 3,5 mg/20 g BW, combination jackfruit leaf and soursop leaf extracts (1+1), and combination (½+½) and metformin 1,3 mg/20 g BW. Blood glucose level was determined every 30 minutes during 2 hours using glucometer. The data were analyzed by ANOVA and Tukey HSD. The result of this study showed that soursop leaf extract at dose 3,5 mg/20 g BW had antihyperglicemic activity better than jackfruit leaf extract and combination of jackfruit and soursop leaves extract. Keywords : jackfruit leaf, Artocarpus heterophyllus Lamk., soursop leaf, Annona muricata L., antihyperglicemic activity.]]>
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