<![CDATA[Pregnancy with HIV infection keeps increasing in the last decades. The main risk factor of transmission is from the mother to the baby due to high viral load in mother circulation system. However, viral load examination with PCR method is very expensive to be conducted. The low immunity system correlates with the increasing HIV viral load. CD4 examination is done to evaluate immune system with a cost-effective method. CD4 percentage provides better information on the overall immune function compared to absolute CD4. The aim of this study was to get accurate alternative examination to predict viral load in HIV infected pregnant women.
A diagnostic study involved 22 HIV infected pregnant women who came to PMTCT Outpatient Clinic Sanglah Hospital, from September 2011 until August 2012 with consecutive sampling. Blood samples were collected to do viral load, CD4, and CBC examination. Viral load examination was done with PCR examination in the molecular biology laboratory in Faculty of Medicine Udayana University. CD4 and CBC examination was done in Sanglah Hospital Laboratory. Analysis was done with 2x2 cross tab using SPSS 17 for windows® version to get sensitivity, specificity, and accuracy range between percentage of CD4 and CD4 absolute to asses HIV viral load.
Analysis result showed that CD4 percentage had got sensitivity 75,0%, specificity 88,9%, and accuracy 86,4% in assessing viral load in HIV infected pregnant women. CD4 absolute had got sensitivity 50,0%, specificity 77,8%, and accuracy 72,7%. Chi-Square analysis showed there was no difference accuracy between CD4 percentage and CD4 absolute (P = 0,457).
Conclusion from this study was that CD4 percentage and CD4 absolute had high accuracy to predict viral load in HIV infected pregnant women. No difference accuracy between CD4 percentage and CD4 absolute.
Keywords: Pregnancy with HIV, viral load, CD4]]>
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