Journal Pharmasci (Journal of Pharmacy and Science)
Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)

Profile of Prescribing Chemotherapy Regimens for High-Risk Acute Leukemia in Children : Profil Peresepan Regimen Kemoterapi Leukemia Akut Risiko Tinggi Pada Anak

Ninik Mas Ulfa (Akademi Farmasi Surabaya)
Eka Sari (Akademi Farmasi Surabaya)



Article Info

Publish Date
26 Jan 2023

Abstract

Cancer is one of the non-communicable diseases but is a health problem in the world, including in Indonesia. The results of the 2018 Basic Health Research showed that the prevalence of cancer rose from 1.4% in 2013 to 1.8% in 2018. Acute Lymphoblastic Leukemia (ALL) is a malignant disease characterized by progressive infiltration of immature lymphoid cells in the bone marrow and lymphatic organs. , with leukocyte cells proliferating irregularly and uncontrollably. This study aims to analyze the descriptive profile of prescribing high-risk ALL chemotherapy regimens in children at a hospital in East Surabaya. This study was conducted on inpatients, chemotherapy regimens using the 2018 ALL National Protocol. The protocol consists of 4 phases of chemotherapy, namely the induction, consolidation, intensification and maintenance phases. The results of the study from the drug administration record data, there were 143 pediatric patients with a diagnosis of ALL. high risk from the period July to August 2022. The most widely used drug classification is the glucocorticoid group with use in the induction phase 38,17%, intensification 43,2%, and maintenance 50%. Dexamethasone was the most used generic name 38,17% was used in the induction phase and 43,2% for the intensification phase. The use of ALL chemotherapy doses is Dexamethasone with doses based on the age of the child, the most being 1 mg (97,62%) and 12 mg (88,10%).

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Journal Info

Abbrev

jps

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. ...