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All Journal Media Kesehatan Masyarakat Indonesia As-syifaa Jurnal Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Community Development Journal: Jurnal Pengabdian Masyarakat International Journal Of Science, Technology & Management (IJSTM) Jurnal ABM Mengabdi Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Pengabdian Kepada Masyarakat Itekes Bali Prosiding Seminar Nasional Biologi Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Strada Jurnal Ilmiah Kesehatan (SJIK)
Ulfa, Ninik Mas
Akademi Farmasi Surabaya
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Profil Peresepan Penyakit Mata Glaukoma pada Pasien BPJS Rawat Jalan (Studi dilaksanakan di RS Mata Masyarakat JawaTimur Periode Januari - Desember 2015) Mustofa, Achmad; Ulfa, Ninik Mas; Suryandari, Mercyska
Journal of Pharmacy and Science Vol. 1 No. 1 (2016): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v1i1.57

Abstract

ABSTRAKGlaukoma adalah penyakit kerusakan saraf optik mata, penyebabnya adalah tingginya tekanan bola mata, diatas 20mmHG. Rata-rata penderita glaukoma adalah glaukoma primer sudut terbuka (POAG) danglaukoma primer sudut tertutup (PACG). Di Rumah Sakit Mata Masyarakat (RSMM) JawaT imur, glaukoma menempati urutan ketiga dalam daftar 10 penyakit terbanyak. Sehingga dilakukan penelitian profil peresepan penyakit mataglaukoma pada pasien BPJS rawat jalan di RSMM Jatim periode Januari- Desember 2015.Penelitian ini bersifat observasional, pengambilan data bersifat retrospektif, penyajian data secara deskriptif. Observasi dengan mengumpulkan resep dokter mata, mencatat usia, golongan obat, nama generik, bentuk sediaan, prosentase obat glaukoma POAG dan glaukoma PACG. Hasil inklusi 2050 resepdan 1461 pasien glaukoma, terdapat 420 pasienglaukoma POAG, 190 pasien glaukoma PACG, dan 851 pasien glaukoma yang lain. Pasien terbanyak usia 61-80 tahun (52,50%), terendah usia ≥81 tahun sebanyak 49 pasien (3,35%). Bentuk sediaan terbanyak, yaitu tetes mata sebanyak 3766 (69,01%). Penggolongan obat terbanyak adalah penyekat β non selektif yaitu Timolol 1783 (32,67%), terendah golongan prostaglandin analog yaitu Travoprost 35 (0,64%). Pada glaukoma POAG, golongan terbanyak adalah golongan penyekat β non selektif yaitu Timolol 203 (29,29%), terendah adalah prostaglandin analog yaitu Latanoprost 83 (11,98%). Pada glaukoma PACG, terbanyak adalah penyekat β yaitu Timolol 81 (29,03%), terendah adalah golongan agonis kolinergik yaitu Pilokarpin 26 (9,32%). Pada penelitian ini disarankan agar dilakukan penelitian lebih lanjut tentang efektifitas peresepan penyakit mata glaukoma di RSMM Jatim.Kata kunci : peresepan glaukoma, glaukoma primer sudut terbuka, glaukoma primer sudut tertutup, klasifikasi obat.ABSTRACTGlaucoma is an eye disease that causes damages to the optic nerve, because high intraocular pressure, above 20mmHg.Glaucoma ranks third in the list of ten most diseases in RSMM. It is important to study the prescription profile of BPJS glaucoma patient in outpatient Eye Hospital in East Java Community period from January to December 2015. The inclusion in 2050 of a prescription, there are 1461 glaucoma patients. 420 with open-angle glaucoma(POAG), 120 patients with close-angle glaucoma (PACG), and 851 patients with others glaucoma. Based on the patient’s age, most patients aged 61-80 years (52.50%), lowest age of ≥81 years in 49 patients (3.35%). Based on the modest dosage forms, namely eye drops as much as 3766 (69.01%). Based on theclassification of drugs, most were non-selective β-blockers ie Timolol 1783 (32.67%), the least class of prostaglandin analogues were Travoprost 35 (0.64%). In POAG, the modest group was non-selective β-blockers ie Timolol 203 (29.29%), carbonic anhydrase inhibitors group, ie Acetazolamide 181 (26.12%), prostaglandin analogues group ie Latanoprost 83 (11.98%). In PACG the modest group was β-blockers, ie Timolol 81 (29.03%), carbonic anhydrase inhibitors group ie Acetazolamide 70 (25.09%), cholinergic agonist group ie Pilocarpine 26 (9.32%). In this study’s suggested that further research on the effectiveness of the prescription of eye disease glaucoma in Community Eye Hospital East Java.Keywords: Glaucoma prescription, primary open angle glaucoma, primary angle-closure glaucoma, drug classification
Studi Efektifitas Antiretroviral Regimen Obat Kombinasi Dosis Tetap (Tenofovir/Lamivudin/Efavirenz) Berdasarkan Peningkatan Kadar Cd4 T-Limfosit (Studi dilakukan di Intalasi Farmasi Rumah Sakit X Surabaya) Wardani, Putri Kusuma; Ulfa, Ninik Mas; Natalia, A.C Aditya
Journal of Pharmacy and Science Vol. 2 No. 1 (2017): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v2i1.62

Abstract

ABSTRAKHIV adalah virus yang secara bertahap menyerang sistem kekebalan tubuh manusia. HIV dapat menyebabkan AIDS (Acquired Immune Deficiency Syndrome) dan sel yang terinfeksi yang memiliki molekul Cluster of Differentiation 4 (CD4). Pengobatan dengan antiretroviral memiliki mekanisme tindakan untuk mencegah replikasi virus yang secara bertahap menurunkan jumlah virus dalam darah. Penelitian ini observasional yang dilakukan secara retrospektif selama 2 tahun (Januari 2014 - Desember 2015) pada pasien HIV / AIDS denganjumlah 51 pasien rawat jalan. Hasil studi observasional menunjukkan bahwa pengobatan dengan antiretroviral regimen obat kombinasi dosis tetap (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) mengalami peningkatan jumlah CD4 selama terapi dan analisis statistik deskriptif menunjukkan bahwa ada perbedaansebelum dan sesudah terapi, sehingga dapat disimpulkan bahwa antiretroviral regimen obat kombinasi dosis tetap efektif.Kata Kunci: HIV / AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.ABSTRACTHIV is a virus that gradually attack the human immune system. HIV can lead to the AIDS (Acquired Immune Deficiency Syndrome) and infected cells that have molecul Cluster of Differentiation 4 (CD4). Treatment withantiretroviral have mechanism of action to prevent replication virus which is step by step decrease the amount of virus in blood. This observasional study conducted retrospectively during 2 years (Januari 2014 - December2015) againt patient HIV/AIDS with 51 outpatients. The result of the observational study showed that treatment with Antiretroviral Fixed Dose Combination (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) had increased CD4 level during therapy and descriptive statistic analysis showed that there was a differences in preand post theraphy, so if could be concluded that Antiretroviral Fixed Dose Combination administration was effective.Key Words: HIV/AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.
Profil Penurunan Tekanan Darah pada Terapi Obat Antihipertensi Golongan CCB Dihidropiridin Antara Amlodipin Dibandingkan Nifedipin Oral Osmotik (Studi Dilakukan di Poli Penyakit Dalam RS Bhayangkara Porong) Ulfa, Ninik Mas; Prasetya, Rahmad Aji; Adelia, Lailatul
Journal of Pharmacy and Science Vol. 3 No. 1 (2018): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v3i1.72

Abstract

ABSTRAKHipertensi adalah suatu peningkatan tekanan darah sistolik dan diastolik yang tidak normal. Tujuan dari penelitian ini adalah untuk mengetahui profil penurunan tekanan darah pada terapi obat antihipertensi yaituAmlodipin dibandingkan Nifedipin Oros dan untuk mengetahui prevalensi efek samping obat. Penelitian ini bersifat observasional. Pengamatan berdasarkan perubahan tekanan darah pre, selama terapi, dan post terapi obat antihipertensi selama 4 bulan terapi. Hasil penelitian tekanan darah pada terapi Amlodipin menunjukkan bahwa mayoritas tekanan darah pre adalah pada kategori hipertensi stage II yaitu 13 pasien (92,86%), setelah 1-2 bulan terapi, tekanan darah mencapai kategori hipertensi stage I, setelah 3 bulan terapi mencapai kategori pre hipertensi, dan pada 4 bulan terapi (tekanan darah post) mayoritas tekanan darah pasien pada kategori pre hipertensi yaitu 13 pasien (92,86%). Sedangkan pada terapi Nifedipin Oros, tekanan darah pasien pada kategori hipertensi stage II yaitu 14 pasien (100,00%), setelah 1-3 bulan terapi, tekanan darah mencapai kategori hipertensi stage I, dan pada 4 bulan terapi (tekanan darah post) mayoritas pasien hipertensi pada kategori pre hipertensi yaitu 13 pasien (92,86%). Berdasarkan analisis statistika deskriptif menunjukkan pola grafik yang sama pada kedua kelompok terapi. Hasil penelitian efek samping obat yaitu hipotensi postural berupa pusing/nyeri kepala dan mual menunjukkan bahwa pada kelompok terapi Amlodipin terdapat 1 pasien (7,14%)yang mengalami efek samping hipotensi postural. Sedangkan pada Nifedipin Oros tidak terdapat pasien yang mengalami efek samping obat. Ini menunjukkan bahwa Amlodipin dan Nifedipin Oros memiliki efek samping obat yang ringan.Kata kunci: Amlodipin, Nifedipin Oros, Profil Tekanan Darah, Hipertensi. ABSTRACTHypertension is a medical situation in which sistolic and diastolic blood pressure is high. This research intended to know, first, the reduction of blood pressure toward antihypertensive medicine such as Amlodipin compare with Nifedipin Oros. Second, to know the prevalence of side effect of the medicines. This study wasobservational research. Observation was based on the changes of “pre” blood pressure, during therapy, and “post” therapy of antihypertensive medicines within 4 months therapy. The result of blood pressure study toward Amlodipin treatment showed that “pre” blood pressure was dominated by hypertensive stage II with 13 patients (92,86%). Furthermore, after 1-2 month therapy, the blood pressure attained to hypertensive stage I. In3 month therapy, the blood pressure reach pre hypertensive category. Moreover, after 4 moth therapy (“post” blood pressure), was dominated by pre hypertensive patients with 13 patients (92,86%). Nevertheless, inNifedipin Oros therapy, most of blood pressure was in the hypertensive stage II ie 14 patients (100,00%). Furthermore, after 1-3 months therapy, the blood pressure attained to hypertensive stage I, then in 4 mothstherapy (“post” blood pressure), was dominated by pre hypertensive patients with 13 patients (92,86%). Based on descriptive statistical analysis showed similar trend in both treatment groups chart. The result of side effects observation was postural hypotension (with signed of headache) and nausea only showed in the Amlodipin therapy, ie 1 patients (7,14%) who got postural hypotension. This showed that Amlodipin and Nifedipin had mild side effects.Key Words: Amlodipin, Nifedipin Oros, Blood pressure profile, Hypertension
Analisis Efektivitas Kontrol Penurunan Tekanan Darah pada Pasien Hipertensi yang Mendapat Terapi Obat Antihipertensi Golongan Angiotensin Receptor Blocker’s (Candersartan, Valsartan, Kalium Losartan) Ulfa, Ninik Mas
Journal of Pharmacy and Science Vol. 2 No. 2 (2017): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v2i2.81

Abstract

ABSTRAKHipertensi adalah peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg pada dua kali pengukuran dengan selang waktu lima menit dalam keadaan cukup istirahat. Faktor penyebab hipertensi adalah faktor gaya hidup, faktor genetika dan faktor usia. Hipertensi termasuk dalam penyakit degeneratif dimana terjadi penurunan organ tubuh. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas kontrol penurunan teakanan darah dari terapi obat Candersartan, Valsartan dan Kalium Losartan. Pada penelitian ini dilakukan di RS X wilayah Surabaya Selatan dan RS Y wilayah Surabaya Timur. Penelitian ini bersifat retrospektif dengan pengamatan observasioanl. Penelitian ini terbagi dalam 3 kelompok terapi dengan jumlah total populasi adalah 57 pasien. Data tekanan darah sistolik-diastolik diamati selama 5 bulan terapi darimasing-masing kelompok terapi A (Candersartan n = 19), kelompok terapi B (Valsartan n= 19), dan kelompok terapi C (Kalium Losartan n= 19).Hasil penelitian menunjukkan bahwa terjadi penurunan tekanan darah sistolik pada kelompok A sebesar 21,18%, kelompok B = 24,20%, dan kelompok C = 22,51%. Penurunan tekanan darah diastolic pada kelompok A sebesar 12,14%, kelompok B = 14,04% dan kelompok C = 10,98%. Berdasarkan hasil analisa statistik diperoleh hasil p = 0,967 > α = 0,05 yang berarti tidak ada perbedaan yang bermakna dari ketiga kelompok terapi tersebut dalam penurunan tekanan darah sistolik maupun diastolik pada pasien hipertensi. Hal ini berarti bahwa efektifitas ketiga obat tersebut dalam kontrol penurunan tekanan darah pada pasien Hipertensi mempunyai efektifitas yangKata Kunci: Candersartan, Valsartan, Kalium Losartan, HipertensiABSTRACTHypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg in two measurements with an interval of five minutes in a resting state. Factors causing hypertension are lifestyle factors, genetic factors and age factors. Hypertension is included in degenerative diseases where there is a decrease in body organs. The purpose of this study was to determine the effectiveness of blood pressure control of Candersartan, Valsartan and Potassium Losartan. This research was conducted in RS X of South Surabaya and RS Y of East Surabaya. This study is retrospective with observational. The study was divided into 3 therapeutic groups with a total population of 57 patients. Data on systolic-diastolic blood pressurewere observed for 5 months of therapy from each of the therapy groups A (Candersartan n = 19), therapy group B (Valsartan n = 19), and therapy group C (Potassium Losartan n = 19). That there was a decrease in systolic blood pressure in group A of 21,18%, group B = 24,20%, and group C = 22,51%. Diastolic blood pressure decrease in group A was 12,14%, group B = 14,04% and group C = 10,98%. Based on the results of statistical analysis obtained results p = 0.967> α = 0.05 which means there is no significant difference of the three groups of therapy in the reduction of systolic blood pressure and diastolic in hypertensive patients. This means that the effectiveness of the three drugs in the control of blood pressure reduction in hypertensive patients has the same effectiveness.Key Words: Candersartan, Valsartan, Potasium Losartan, Hypertesion
Anealisis Uji Pendahuluan Aktivitas Antikanker Ekstrak Biji Pepaya (Carica papaya L) dengan Metode BSLT Ulfa, Ninik Mas; Kusumo, Galuh Gondo; Zulfa, Ilil Maidatuz
Journal of Pharmacy and Science Vol. 4 No. 1 (2019): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v4i1.122

Abstract

ABSTRAKTumbuhan pepaya (carica papaya L) merupakan tumbuhan tropis yang banyak terdapat di Indonesia. Tumbuhan ini mempunyai banyak manfaatnya mulai dari buah, biji, hingga daunnya. Penelitian pendahuluan menyebutkan buah pepaya mengandung alkaloid dan flavonoid yang berkhasiat sebagai antikanker. Senyawa BenzylIsothiocyanat diketahui banyak terdapat pada biji dan buah pepaya yang sudah matang. Kandungan BenzylIsothiocyanat mempunyai khasiat sebagai antikanker. Pemanfaatan limbah biji pepaya pada penelitian ini untuk membuktikan aktivitas Benzyl-Isothiacyanat yang berkhasiat sebagai antikanker. Penelitian ini merupakan penelitian pendahuluan untuk menganalisis aktivitas antikanker dari Ekstrak kental biji pepaya dengan menggunakan metode BSLT. Konsentrasi ekstrak kentak yang digunakan yaitu 100 ppm, 200 ppm dan 300 ppm masing-masing diujikan pada 10 larva udang dalam air laut. Diperoleh hasil rata-rata kematian pada konsentrasi 100 ppm adalah 4,3, 200 ppm adalah 5,3 dan 300 ppm adalah 6,7. Hasil regresi linearitas menunjukkan aktivitas antikaker pada uji BSLT dari Ekstrak kental biji pepaya dengan LC50 sebesar 163,89 ppm. Dengan demikian ekstrak kental biji pepaya tersebut berpotensi untuk dikembangkan sebagai bahan antikanker alamiKata kunci: Aktivitas antikanker, Carica papaya, metode BSLT.ABSTRACTPapaya plant (carica papaya L) is a tropical plant that is widely found in Indonesian. This plant has many benefits ranging from fruit, seeds, to leaves. Preliminary research says papaya fruit contains alkaloids andflavonoids which are efficacious as anticancer. Benzyl-Isothiocyanat compounds are known to be widely found in ripe papaya seeds and fruit. The content of Benzyl-Isothiocyanat has properties as an anticancer. The use of papaya seed waste in this study is to prove the activity of Benzyl-Isothiacyanat which is efficacious as an anticancer. This research is a preliminary study to analyze the anticancer activity of thick papaya seeds using the BSLT method. The concentrations of used fart extracts were 100 ppm, 200 ppm and 300 ppm each tested on 10 shrimp larvae in seawater. The results of the average mortality at concentrations of 100 ppm were 4.3, 200 ppm were 5.3 and 300 ppm was 6.7. The linearity regression results showed the anticaker activity in the BSLT test from the thick extract of papaya seeds with LC50 of 163.89 ppm. Thus the thick extract of papaya seeds has the potential to be developed as a natural anticancer material.Key Words : Anticancer activity, BSLT method, Carica papaya.
Efektivitas Penggunaan Oral Antidiabetes Kombinasi Glimepiride Dengan Pioglitazone Pada Pasien Dibetes Mellitus Tipe 2 Mas Ulfa, Ninik; Arfiana, Nabila
Journal of Pharmacy and Science Vol. 5 No. 1 (2020): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v5i1.154

Abstract

Diabetes mellitus is a disorder of chronic metabolic syndrome from carbohydrates, lipids and fats resulting from the deficiency of insulin in the body so that it can cause hyperglycemia. Oral Antidiabetic and Insulin is pharmacological therapy that can control blood sugar levels. This study aims to observe the effectiveness of Glimepiride combination therapy with Pioglitazone in type 2 DM patients with fasting blood Glucose and blood Glucose 2 hour post prandial parameters compared to pre and post values. This research method is observational with retrospective data collection and data analyzed descriptively. The sample size was 30 type 2 DM patients who received therapy after 6 months. The results showed that there were significant differences between the value of fasting blood Glucose pre and fasting blood Glucose post and blood Glucose 2 hour post prandial pre and blood Glucose 2 hour post from statistical analysis using paired t-test, with a value of α = 0.00 smaller than α = 0.05. This shows that the combination of Glimepiride with Pioglitazone is effective in blood glucose control in type 2 DM patients. Keywords: Dibetes Mellitus, Oral Antidiabetic, Glimepiride, Piogliatzone
Analysis Of The Effect Of Age On Medication Adherence With Oral Antidiabetes And Oral Antihypertension Drugs Using Pill Count Method: Analisis Pengaruh Usia terhadap Kepatuhan Minum Obat Oral Antidiabetes dan Oral Antihipertensi Menggunakan Metode Pill Count Mas Ulfa, Ninik; Darmawan, Rizky
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.216

Abstract

Compliance with taking medication is a problematic patients who get polypharmacy prescribing, this is because of the many drugs that must be consumed. As a result of the consumption of many drugs that cause sufferers of degenerative diseases are not compliant to take medication and health awareness decreases. This is not only experienced in elderly and geriatric patients but in adulthood also experience non-compliance with taking medication due to the many activities, lazy to take medication and also forget. This study was conducted to analyze the effect of age on adherence to taking oral antidiabetic drugs and oral antihypertensive drugs using the pill count method at the Regional Hospital of South Surabaya. The Pill Count method was chosen in this study with the aim of analyzing patient compliance in taking medication by calculating the remaining drug based on the rules of use and dosage when the patient returns to control. In addition, this study also aims to determine the effect of age on patient compliance in taking oral antidiabetic drugs and oral antihypertensive drugs. This research is descriptive observational with prospective data collection. Data analysis used descriptive and continued with statistical analysis using Chi-Square. The results of this study that adherence to take medication for elderly patients who received oral antidiabetic drug therapy obtained as much as 96.7% and 90% in adult patients. Compliance to oral antihypertension drugs in adult patients are 90% and 83.3% in elderly patients. Age does not effect compliance patients with Chi-Square analysis with p value = 0,301 and 0,448 > 0.05.
ANALISIS EFEKTIFITAS CEFAZOLINE, CEFTRIAXONE, CEFOTAXIME SEBAGAI ANTIBIOTIK PROFILAKSIS PADA PASIEN SECTIO CAESAREA Ninik Mas Ulfa; Selly Septi Fandinata; Yuni Hendrawati
As-Syifaa Jurnal Farmasi Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v11i2.567

Abstract

Prophylactic antibiotics is very necessary in labor with the aim of avoiding infection during SC surgery. This study was descriptive observational with retrospective data collection. The subjects observed in this study were medical records documents of SC patients in RJI hospitals in the area of South Surabaya for the period February - April 2017, with 39 documents were divided into 3 groups. Group A which received Cefazolin, Group B received Ceftriaxone, and Group C which received Ceftaxime. This study was comparison of the effectiveness of these 3 prophylactic antibiotics was measured by temperature parameters, leukocytes and observation of the condition of the surgical wound. Based on statistical analysis using the Kruskal Wallis test, it was found that the effectiveness of antibiotic prophylaxis Cefazolin was more effective in reducing the temperature and leukocytes of SC patients compared to Ceftriaxon and Cefotaxim, with an average rating of Cefazolin in temperature parameters of 27.58 and an average ranking in leukocyte parameters ie 25.81. Meanwhile in observing surgical wounds from three groups of antibiotic prophylaxis there was no redness, no swollen wounds, no discharge and no pus from surgical wounds
Profil Penggunaan Obat Antianemia, Antihipertensi, dan Antidiabetik pada Pasien Penyakit Ginjal Kronik di Salah Satu Rumah Sakit Wilayah Surabaya Selatan Ninik Mas Ulfa; Iin Ernawati; Purwanti Purwanti; Riki Kurniawanto; Ari Indrawati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 16 No. 02 Desember 2019
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v16i2.5724

Abstract

Penyakit ginjal kronis (PGK) merupakan gangguan fungsi renal yang progresif dimana kemampuan tubuh gagal untuk mempertahankan metabolisme dan keseimbangan cairan elektrolit dan menyebabkan uremia. Tujuan penelitian ini untuk mengetahui profil penggunaan obat antianemia, antihipertensi, dan antidiabetik pada pasien PGK dengan hemodialisa. Penelitian ini dilakukan di Rumah Sakit Wilayah Surabaya Selatan. Penelitian ini bersifat deskriptif observasional menggunakan data secara retrospektif, pada bulan Januari-Maret 2018. Berdasarkan hasil penelitian diperoleh pada pemakaian obat antianemia dengan menggunakan  EPO alfa 2000 IU dan 3000 IU, keduanya dapat meningkatkan kadar Hb. Variasi dosis EPO alfa yang digunakan yaitu dosis 2000 IU sebanyak 60% pasien dan 3000 IU sebanyak 40% pasien. Untuk obat antihipertensi pemakaian terbanyak kombinasi irbesartan 300 mg dan amlodipine 10 mg dengan frekuensi pemberian 1 kali sehari 1 tablet. Antidiabetik yang digunakan pada pasien PGK adalah kombinasi insulin basal dan prandial sebanyak 80% daripada terapi OAD atau insulin tunggal. Pada golongan sulfonilurea digunakan gliquidone dosis 30 mg dengan frekuensi satu kali sehari (20%). Golongan insulin paling banyak diberikan adalah kombinasi insulin analog kerja panjang dan insulin aspart analog kerja cepat (34%).
Pengaruh Metode Medication Picture dengan Metode Pill Count terhadap Kepatuhan Pasien Lansia dalam Penggunaan Obat Oral Antidiabetes dan Oral Antihipertensi Ninik Mas Ulfa; Eziah Ika Lubada; Rizky Darmawan
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.8620

Abstract

Kepatuhan minum obat sangat menentukan keberhasilan terapi, terutama pada pasien lansia. Penelitian ini dilakukan untuk menganalisis pengaruh tingkat kepatuhan pasien lansia dalam menggunakan obat oral antidiabetes (OAD) dan obat oral antihipertensi. Metode kepatuhan yang digunakan adalah metode medication picture dan metode pill count. Penelitian ini bersifat observasional dengan pengambilan data secara prospektif. Besar sampel yang memenuhi kriteria inklusi sebanyak 60 pasien lansia, yang terbagi menjadi 2 kelompok. Kelompok A merupakan pasien lansia yang mendapat metode medication picture dan kelompok B mendapatkan metode pill count. Hasil penelitian dengan analisis chi square diperoleh bahwa metode medication picture dapat meningkatkan kepatuhan minum obat oral antidiabetes pasien lansia sebesar 93,3% dengan p value < 0,05 dibandingkan dengan metode pill count 63,3%. Tetapi pada kepatuhan minum obat oral antihipertensi dari kedua metode tersebut tidak memberikan perbedaan yang signifikan dengan nilai p value > 0,05.
Co-Authors ., Syukrianto Adelia, Lailatul Arfiana, Nabila Ari Indrawati Aristyawan, Andhika Dwi Aryanda Putra, Deddy Deddy Aryanda Putra Diana Rahmawati Eka Sari Eziah Ika Lubada Galuh Gondo Kusumo Iin Ernawati Indra Puspitasari, Indra Mercyska Suryandari Meyke Herina Syafitri Mustofa, Achmad Natalia, A.C Aditya Primanitha Ria Utami Purwanti Purwanti Puspa Novita, Rennie Rahmad Aji Prasetya Riki Kurniawanto Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan, Rizky Septi Fandinata, Selly Surahmaida, Surahmaida Suryadari, Mercyska Syukrianto, Syukrianto Umar, Umarudin Umarudin, Umarudin Wardani, Putri Kusuma Yuni Hendrawati Zulfa, Ilil Maidatuz