High Levels of Leucocyte and Thrombocyte Increasing COVID-19 Mortality Rate in RSUP Dr. M. Djamil Padang

Maulana Muharam (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas)
Sabrina Ermayanti (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas)
Afriani Afriani (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas)

Jurnal Respirologi Indonesia
Vol 43, No 1 (2023)

Background: Different leukocytosis, leucopenia, thrombocytosis, thrombocytopenia, and clinical severity appear in COVID-19's cases. This study is aimed to identify the association between leucocyte, thrombocyte, and clinical severity in COVID-19's outcome.Methods: A retrospective cohort study involving 121 patients with COVID-19 whom admitted from January to March 2021. Kruskal Wallis test was applied for analysis.Results: The majority of participants were female (55.4%), aged between 18-49 years old (42.1%), and had comorbidities (81.8%). Most participants had a normal range of leucocyte (57.9%), thrombocyte (62.8%), and moderate clinical severity (67.8%). Subjects with full recovery were 79.3%, with sequelae such as weakness, and/or shortness of breath 3.3%, and deceased 17.4%. Leucocyte and thrombocyte had an association with COVID-19 outcome (P=0.045 and P=0.030 respectively). Clinical severity had no association with COVID-19 outcome (P=0.304). Conclusion: Leucocyte and thrombocyte have an association with COVID-19 outcome. Clinical severity has no association with COVID-19 outcome.