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All Journal Jurnal Kesehatan Andalas Jurnal Farmasi Klinik Indonesia Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Human Care Journal Unri Conference Series: Community Engagement Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)

Ermayanti, Sabrina

Bagian Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia

Author-ID : 902697

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF PULMONARY FUNGUS BALL RELATED TUBERCULOSIS Fenty Anggrainy; Irvan Medison; Deddy Herman; Sabrina Ermayanti; Yessy Susanty Sabri
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.1025

Fungus Ball paru merupakan komplikasi yang sering terjadi pada Tuberkulosis (TB) paru dengan kavitas, terutama pada bekas TB paru. Agen penyebab selain Aspergilus sp yaitu Candida sp. Terapi definitif untuk penyakit ini adalah terapi bedah. Pada kondisi khusus dapat digunakan tatalaksana lainnya. Penelitian ini mengevaluasi 6 pasien Fungus Ball paru dengan riwayat obat anti tuberkulosis, dengan beberapa metode diagnosis dari tahun 2010 sampai 2013. Tatalaksana dan hasil pengobatan pasien dianalisis pada penelitian ini. Hemoptisis terdapat pada seluruh pasien dan tiga diantaranya dengan hemoptisis masif. Semua pasien memiliki gambaran yang khas untuk Fungus Ball paru dari radiologi toraks. Spesies jamur terkonfirmasi pada 5 pasien: pemeriksaan serologis (1), kultur jamur (2) dan pemeriksaan histopatologi (2). Spesies yang didapatkan adalah Aspergilosis sp = 3, Candida paraspilosis = 1 dan Candida sp = 1. Dua pasien mendapatkan terapi bedah dengan tidak adanya keluhan hemoptisis setelah itu. Empat pasien yang hanya mendapatkan anti jamur, ternyata 75% memberikan respon yang baik secara klinis dan radiologis. Kavitas yang menetap pada TB paru dan bekas TB paru, dapat menimbulkan insiden Fungus Ball paru yang membutuhkan lobektomi sebagai terapi definitif. Pada kondisi tertentu dimana terapi pembedahan tidak dapat dilakukan, anti jamur dapat menjadi terapi alternatif dan memberikan hasil yang baik.

Hematologic Toxicities of Chemotherapy in Lung Cancer Patients: A Retrospective Study in Dr. M. Djamil Hospital Padang, Indonesia Yori Yuliandra; Hansen Nasif; Sabrina Ermayanti; Lilik Sulistyowati; Dian A. Juwita
Indonesian Journal of Clinical Pharmacy Vol 8, No 2 (2019)
Publisher : Universitas Padjadjaran

The use of chemotherapeutic agents in the management of cancer is often followed by a range of toxicities to various organ systems. A retrospective study on the hematologic toxicities of chemotherapy in lung cancer patients has been carried out. The study was conducted by a cross-sectional method from medical records of four-year data in 2010–2014 at Dr. M. Djamil Hospital Padang, West Sumatra, Indonesia. Data from medical records of patients diagnosed with lung cancer and underwent chemotherapy, not suffering from primary hematologic diseases, and with normal kidney and liver function prior to chemotherapy were studied. A number of 22 medical records of lung cancer patients which met the criteria with a total of 40 chemotherapy cycles were observed. The study revealed that a combination of carboplatin-paclitaxel was the most common chemotherapy used for the patients (72.7%). The hematologic toxicities comprised anemia, leukopenia, and thrombocytopenia with the severity ranging from grade 1–3. Carboplatin-paclitaxel was the only combination that caused these three toxicities, and the only combination to cause thrombocytopenia as well. Anemia was the major hematologic toxicity experienced by more than half of the patients. The study concludes that there is a reasonably high incidence of hematologic toxicities from chemotherapy among lung cancer patients.Keywords: Anemia, chemotherapy, hematologic toxicity, leukopenia, lung cancer, thrombocytopenia Toksisitas Hematologis Akibat Kemoterapi pada Pasien Kanker Paru: Studi Retrospektif di RSUP Dr. M. Djamil PadangAbstrak Penggunaan obat kemoterapi dalam pengobatan kanker sering disertai dengan toksisitas pada beberapa sistem organ. Kajian retrospektif terhadap toksisitas hematologis akibat kemoterapi pada pasien kanker paru sudah dilaksanakan. Studi ini dilaksanakan dengan metode cross-sectional dari data rekam tahun 2010–2014 di RSUP Dr. M. Djamil Padang, Sumatera Barat. Data pasien yang didiagnosis menderita kanker paru yang menjalani kemoterapi, tidak menderita penyakit hematologis dan gangguan hematopoiesis, serta memiliki fungsi ginjal dan hati yang normal dimasukkan ke dalam kajian. Sejumlah 22 pasien memenuhi kriteria dengan jumlah siklus kemoterapi sebanyak 40. Hasil kajian ini mengungkap bahwa kombinasi karboplatin-paklitaksel merupakan kemoterapi yang paling banyak digunakan (72,2%). Toksisitas hematologis yang terjadi meliputi anemia, leukopenia, dan trombositopenia dengan tingkat keparahan 1–3. Karboplatin-paklitaksel merupakan satu-satunya kombinasi kemoterapi yang menyebabkan ketiga toksisitas hematologis tersebut, sekaligus juga merupakan satu-satunya kombinasi yang menimbulkan trombositopenia. Anemia merupakan toksisitas hematologis yang paling banyak terjadi meliputi lebih dari separuh pasien. Penelitian ini menyimpulkan bahwa terdapat toksisitas hematologis yang cukup tinggi akibat kemoterapi pada pasien kanker paru.Kata kunci: Anemia, kanker paru, kemoterapi, leukopenia, toksisitas hematologis, trombositopenia

PENYULUHAN BAHAYA MEROKOK DALAM RANGKA PERINGATAN HARI PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK) SEDUNIA DAN BULAN PEDULI KANKER PARU Russilawati Russilawati; Sabrina Ermayanti; Masrul Basyar
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 4 No 2 (2020)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.4.2.356-366.2020

Padang Municipality has been making effort to improve quality of life for its citizens by providing out door facility trough weekly car free day program. Even though it is supposed to be fresh air there were many visitors still smoking tobacco so that caused air pollution. Tobacco smoking has been known as major risk factor for Chronic Obstructive Pulmonary Disease (COPD) and lung cancer. In addition tobacco smoking has been considered to have association with twenty millions premature deaths. Our objectives were to outspread knowledge about hazard of tobacco and smoking cessation campaign in commemoration of COPD word day and month of lung cancer care 2018. Counseling was implemented by presentation, discussion, leaflet, and quiz with door prize. Meanwhile, smoking cessation campaign was performed by waking around and giving present to individu who willingly put out the cigarette at the moment. Total 155 visitors were involved in the event. They were classified in three groups of never smoker, former smoker or current smoker. Furthermore, 74 self identified current smokers were assessed in regard of grade of smoking, nicotine dependence, and motivation to smoke by using standardized questioner. Analysis of interview found out most of visitors were mild smoker with low nicotine dependence, and had motivation for smoking by social influence and stress relief. The data could be considered in choosing smoking cessation program for community. Keyword: tobacco smoking, nicotine, COPD, lung cancer

Mediastinal Tumor Thymoma Type B1 T4N2M1B Stage IVB with Multimodality Therapy Muhammad Zakki Al-Fajri; Sabrina Ermayanti; Afriani Afriani
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 23 No. 01 (2022): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

The incidence of thymoma increases with age, generally occurs in the 40-60s. Thymoma cases are rare at a young age. The prevalence of thymoma at a young age is very small at 0.6 – 5% of all thymoma cases. Thymoma management requires multimodality therapy depending on the stage of the thymoma, along with the development of surgery, radiotherapy and chemotherapy in the past three decades. A 21-year-old male patient with complaints of shortness of breath since 5 months before being admitted to the hospital. The patient has been diagnosed with thymoma type Mediastimum Tumor Type B1 T4N2M1B stage IVB from the results of chest X-ray investigations, chest CT scan, bronchoscopy and histopathological examination. The patient has received various therapeutic modalities including 6 cycles of chemotherapy, 30 radiotherapy and thymectomy surgery

The Differences of Respiratory Symptoms and Pulmonary Impairment between Exposure and Unexposured Areas by Dust from Semen Padang Factory Dian Citra; Irvan Medison; Sabrina S Ermayanti
Jurnal Respirologi Indonesia Vol 38, No 3 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Background: The cement factories have a waste product such as dust that had negative impact on respiratory system. The aims of this study is to investigate the differences of respiratory symptoms and pulmonary impairment between exposure and unexposured region by dust from Semen Padang factory. Methods: Cross sectional study of 282 subjects from exposure and unexposure areas in Semen Padang factory. This study was held in March 2016 - July 2017. Dust levels were assessed at both areas. Respiratory symptoms were assessed by interviews and quistionnaires. Lung function was measured by spirometry examinations. The variables between both groups were analyzed. Results: The daily dust level of exposure area close to three folds than unexposure area (150μg/Nm 3 vs 53,50 μg/Nm 3) yet still in save level that assigned by regulation. There were 282 subjects from both areas which consist of 67 men and 74 women for each area. There were no differences in respiratory symptoms included chest pain (0% vs 0,7%, P=1,00), productive cough (4,3% vs 2,1%, P=0,5), cronic cough (4,3% vs 2,1% ,P=0,5) and breathlessness (5,7% vs 5% ,P=1,00). The proportion of pulmonary impairment not difference between two areas (P=0,053). Concusions: Both area had dust level below up level assigned by regulation. There were no differences in respiratory symptoms and pulmonary impairment at exposure area and unexposure area. Breathlessness is most common symptom.

Layanan Hotline Konsultasi Masalah Kesehatan Pasca COVID-19 Sabrina Ermayanti; Russilawati Russilawati; Fenty Anggraini; Afriani Afriani; Irvan Madison; Oea Khairsyaf; Masrul Basyar; Deddy Herman; Yessy Susanty Sabri; Dewi Wahyu Fitrina; Dessy Mirzati; Elsa Purnama Sari; Dimas Bayu Firdaus
Unri Conference Series: Community Engagement Vol 3 (2021): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.3.296-302

Pandemy of Corona virus disease 2019 (Covid-19) has overwhelmed the word for nearly two years. Indonesia is one countries that been hit hard by Covid-19. Even though most of patients with positive test of Covid-19 had no symptoms or mild some of them reported persistent clinical symptoms months after test negative. This population with disorder whose terminology Long Covid-19 need health care to help them cope with this condition. In this need Department of Pulmonology and Respiratory medicine initiate community service activity for Covid-19 survival with Long Covid-19 in the formulation Hotline Service on Post Covid-19 Health Problem. Survivors of Covid-19 who accessed this service originated from variety geographic region in Indonesia. This Activity reached 60 survivors were mostly female (57%), in age group of young adult (62%) and dominant with mild symptoms (58%). Recommendation for these survivors whose mild symptoms was self care observation. There were still about 25 survivors (42%) who need further health care with appropriate speciality.

GAMBARAN STATUS, DERAJAT DAN PROFIL MEROKOK SERTA KETERGANTUNGAN NIKOTIN PADA PASIEN PEROKOK YANG DIRAWAT DI BANGSAL PARU RSUP DR. M. DJAMIL PADANG Sur Yastri; Sabrina Ermayanti; Russi lawati
HUMAN CARE JOURNAL Vol 4, No 3 (2019): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v4i3.592

Smoking was still health major problem in the word that lead 7.1 million smoking related deaths annually. Prevalence smoking in Indonesia was fifth in the world. Based on Riskesdas in 2007 and 2010 showed an increase number of smokers from 29% - 34.7%. Methods: This is Descriptive-prospective study in 177 patients who were treated in pulmonary ward of Dr. M. Djamil Padang from November 2016 to January 31, 2017. Data were collected through interviews patients with closed questions and validated questioner. Results: This study found total 177 patients that consist of 128 (72.4%) males with an average age of 52.5 ± 15.57 SD years. History of smoking were 63 smokers (35.6%), 67 nonsmokers (37.8%) and former smokers 47 (26.5%). Smoker patients have been found most in bronchogenic carcinoma patients 24 (38%), with profile for stress 34 (54%), and the Brinkman index grade was severe. Former smokers were mostly in patients with pneumonia 11 (23.4%) and COPD 10 (21.2%). The nicotine dependence is low to moderate 13 (56.5%) in patients with bronchogenic carcinoma and low dependence 10 (53%) in TB patients. Conclusion: Patients that were treated in the pulmonary ward more than third were smokers. The most common profile was for pleasure and nicotine dependence mostly low to moderate could give opportunity for educational intervention.

Accuration of Circulating Tumor DNA (ctDNA) in Detection of Epidermal Growth Factor Receptor (EGFR) Mutation in Lung Cancer Patient Type Adenocarcinoma in M Djamil Hospital Padang Yandra Darusman; Sabrina Ermayanti; Sari Nikmawati; Afriani Afriani
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.6

Background: ctDNA is an alternative test for detecting mutation of EGFR in lung cancer type adenocarcinoma if the tissue speciment can not be carried out. Sensitivity, specificity and accuration of ctDNA test is stil varied. This study is aimed to acknowledge sensitivity, specificity and accuration of ctDNA in detecting EGFR mutation in patient with lung cancer type adenocarcinoma in M Djamil Hospital. Methods: Design this study a diagnostik test comparing ctDNA to tissue speciment in detection EGFR mutation of 42 patients with lung cancer type adenocarcinoma in M Djamil Hospital. Sample was selected through consecutive technique. Results: Incidence of EGFR mutation in patients with lung cancer type adenocarcinoma from tissue speciment was higher than ctDNA ((42,9% vs 28,6%; p=0,031). There was significant diffierence of EGFR mutation detection between sex, smoking status, and TNM staging based on tissue/cytology examination and ctDNA (p=0,031). EGFR mutation in sitologic test and ctDNA was more likely detected in male patient (66.7% and 58.3%), ex-smoker (50% and 41.7%) and stage IV (88.9% and 91.7%). The results of sensitivity, specificity positive prediction value (PPV) and Negative prediction value (NPV) in ctDNA test to detect EGFR mutation were 66,7%, 100%, 100% dan 80% according to sitology test as gold standard. Furthermore, the ctDNA accuration was measured according to AUC score 0.833 (SE 0,072, CI 95%, 0,693-0,974, p=0.0001). Conclusion: ctDNA test have a good accuration with sensitiviy 66.7% and specificity 100% in detecting EGFR mutation in patients with lung cancer type adenocarcinoma.

Faktor − Faktor yang Mempengaruhi Kejadian Gagal Napas pada Pasien PPOK Eksaserbasi Akut di RSUP Dr. M. Djamil Padang Mirtha Anggraeni; Russilawati Russilawati; Sabrina Ermayanti
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 1 (2020): Maret 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Eksaserbasi akut pada pasien PPOK menjadi faktor risiko untuk kejadian gagal napas. Pasien PPOK eksaserbasi akut dengan gagal napas memiliki status kesehatan yang lebih buruk dan morbiditas yang lebih tinggi. Objektif. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kejadian gagal napas pada pasien PPOK eksaserbasi akut di RSUP Dr M Djamil Padang. Metode. Penelitian ini merupakan studi kasus kontrol menggunakan data sekunder dari rekam medis RSUP Dr M Djamil Padang periode Januari 2016 - Desember 2017. Penelitian ini melibatkan 53 subjek pada masing-masing kelompok kasus (gagal napas) dan kelompok kontrol (tanpa gagal napas). Analisis data menggunakan analisis x2. Hasil. Karakteristik kelompok kasus dan kontrol tidak memiliki perbedaan yang bermakna, yang terdiri dari jenis kelamin (p=1,000), usia (p=0,804), status merokok (p=0,127), dan derajat merokok (p=0,942). Riwayat eksaserbasi akut ≥1 kali dalam satu tahun sebelumnya lebih banyak pada kelompok kasus dibandingkan dengan kelompok kontrol (86,8% vs 67,9%; p=0,037; OR = 3,103;95% CI = 1,162-8,288). Kelompok kasus lebih banyak yang meninggal dibandingkan dengan kelompok kontrol (50,9% vs 3,8%; p=0,000). Faktor risiko independen yang dianalisa adalah status merokok (p=0,974; OR=0,981), riwayat eksaserbasi (p=0,007; OR=4,169), dan terapi rumatan (p=0,024; OR=0,359). Kesimpulan. Riwayat eksaserbasi dalam satu tahun sebelumnya pada pasien PPOK eksaserbasi akut merupakan faktor risiko independen terjadinya gagal napas. Hasil luaran pada kelompok kasus lebih buruk dibandingkan dengan kelompok kontrol. Kata kunci: gagal napas, PPOK eksaserbasi akut, riwayat eksaserbasi dalam satu tahun sebelumnya

Benefits of Conventional Chemotherapy in Progressive Disease Patients with Tyrosine-Kinase Inhibitors: A Case Report Ahmad Junaidi; Sabrina Ermayanti; Afriani Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.657

Background. Mutation of the epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma is a favorable predictive factor for targeted EGFR tyrosine kinase inhibitor (TKI) therapy, but patients with EGFR-mutated lung cancer who are given EGFR-TKI will experience disease progression after average 10 to 14 months on average. This study aims to describe a case of progressive lung adenocarcinoma and its chemotherapy treatment. Case presentation: A 54 years old woman who came with stage IV left lung adenocarcinoma (exon 21 mutation) who had received EGFR TKI for 17 months progressed, so the treatment was shifted to systemic chemotherapy. Based on these diagnostic results, the patient was diagnosed with progressive disease T3N1M1c left lung adenocarcinoma (pleura, contralateral nodule, ribs, suprarenal) Stage IVb PS ECOG 0. The patient was then treated with conventional doublet-platinum-based chemotherapy with the Carboplatin-Paclitaxel combination. Conclusion: Systemic chemotherapy with doublet-platinum is an option in patients with progressive adenocarcinoma with EGFR-TKI who cannot obtain tissue for histopathological examination at rebiopsy or do not have access to advanced molecular biology (e.g., T790M) or follow-up therapy (third-generation TKI, osimertinib).

Co-Authors Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Afriani Ahmad Junaidi Amellya Sucieta Ana Rima Andreas Infianto Arif Santoso Armiza Dessy Mirzati Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dian A. Juwita Dian Citra Dimas Bayu Firdaus Dolly Irfandy Elisna Syahruddin Elsa Purnama Sari Elsesmita Fenty Anggraini Fenty Anggraininy Fenty Anggrainy Ferry Dwi Kurniawan Hamni Tanjung Hansen Nasif Haryati Haryati Hendris Utama Citra Wahyudin Herman, Deddy Ida Ayu Jasminarti Irvan Madison Irvan Medison Irvan Medison Irvan Medison Isnaniyah Usman Julizar Julizar Laisa Azka Laksmi Wulandari Lilik Sulistyowati Mahata, Liganda Endo Masrul Basyar Masrul Basyar Maulana Muharam Mirtha Anggraeni Muhammad Farhan Ramadhan Muhammad Zakki Al-Fajri Nathaniel Aditya Noni Novisari Soeroso Oea Khairsyaf Russi lawati Russilawati, Russilawati Sari Nikmawati Setyawan, Ungky Agus Sita Andarini Sri Melati Munir Sukri Rahman Sur Yastri Syandrez Prima Putra Yandra Darusman Yessy Susanty Sabri Yori Yuliandra Zaini, Jamal

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