<![CDATA[Background: COVID-19 has become a primary public health issue in various countries across the world. The main difficulty in managing outbreaks of infectious diseases is due to the difference in geographical, demographic, economic inequalities and people's behavior in each region. The spread of disease acts like a series of diverse regional outbreaks; each part has its disease transmission pattern. Objective: This study aims to assess the association of socioeconomic and demographic factors to COVID-19 cases through cluster analysis and forecast the daily cases of COVID-19 in each cluster using a predictive modeling technique. Methods: This study applies a hierarchical clustering approach to group regencies and cities based on their socioeconomic and demographic similarities. After that, a time-series forecasting model, Facebook Prophet, is developed in each cluster to assess the transmissibility risk of COVID-19 over a short period of time. Results: A high incidence of COVID-19 was found in clusters with better socioeconomic conditions and densely populated. The Prophet model forecasted the daily cases of COVID-19 in each cluster, with Mean Absolute Percentage Error (MAPE) of 0.0869; 0.1513; and 0.1040, respectively, for cluster 1, cluster 2, and cluster 3. Conclusion: Socioeconomic and demographic factors were associated with different COVID-19 waves in a region. From the study, we found that considering socioeconomic and demographic factors to forecast COVID-19 cases played a crucial role in determining the risk in that area. Keywords: COVID-19, Facebook Prophet , Hierarchical clustering, Socioeconomic and demographic]]>
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