Makara Journal of Science
Vol. 11, No. 2

STUDI IN SILICO MODIFIKASI POS TRANSLASI DISAIN VAKSIN CHIMERIC BERBASIS VIRUS LIKE PARTICLES HUMAN PAPILLOMAVIRUS DENGAN KAPSID VIRION L1

Tambunan, Usman Sumo Friend (Unknown)
Parikesit, Arli Aditya (Unknown)
Tochary, Theo A. (Unknown)
Sugiono, Dedy (Unknown)

Article Info

Publish Date
25 Nov 2007

Abstract

Computational Study of Post Translation Modification in Chimeric Virus Like Particles Vaccine of Human Papilloma Virus with Virion Capsid L1. The Human Papillomavirus (HPV) infection has a tight correlation with the incidence of cervical cancer. Chimeric virus like particles (cVLP) has been developed as vaccine candidate for preventing cervical cancer. cVLPs are improvement of Virus Like Particles (VLP) by substituting the epitope of L1 HPV -18 and -52 protein to L1 HPV -16 protein. They are ANN1, ANN2, HMM1, and HMM2. The impact of post translation modification will be determined. Based on In Silico study, the dominant post translation modification is glycosylation

Copyrights © 2007




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Journal Info
Makara Journal of Science
Website

Abbrev

publication:science

Publisher

Universitas Indonesia

Subject

Description

Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and ...