Jurnal Ilmu Kefarmasian Indonesia
Vol 21 No 1 (2023): JIFI

Efek Sindrom Antimetabolik Ekstrak Daun Etanol 70% Ficus carica Linn. pada Tikus yang Diinduksi Streptozotocin dan Diet Tinggi Lemak

Rahmatul Qodriah (Faculty of Pharmacy Universitas Pancasila)
Shirly Kumala (Faculty of Pharmacy, University Pancasila)
Syamsudin Syamsudin (Faculty of Pharmacy, University Pancasila)
Nancy Dewi Yuliana (Faculty of Pharmacy, University Pancasila)
Vyacheslav Dushenkov (International Research Training Center for Botanicals and Chronic Diseases (CBCD), Rutgers University)
Carrista Carrista (Faculty of Pharmacy, University Pancasila)



Article Info

Publish Date
11 May 2023

Abstract

Diabetes and obesity are risk factors for metabolic syndrome. Fig (Ficus carica L.) one of the plants is well known in traditional medicine system for their medicinal and therapeutic potentials. Fig leaves contain flavonoid and triterpenoid compounds which have antimetabolic effect. Streptozotocin is used to make diabetogenic rats to produce hyperglycemia conditions in test animals and high-fat diet to make rats model obesity. This study aimed to test the antidiabetic and antiobesity effect of 70% ethanol extract of fig leaves based on the parameters of measuring blood glucose levels with glucometer and Cholesterol strips. In thisstudy, rats were divided into 6 groups, namely normal, negative, positive control, and 3 control groups at 70%ethanol extract dose level (250, 500, and 600 mg/kgBW) per oral. The measurement results in normal, negative, and positive control dose of 250, 500, 600 mg/kgBW at blood glucose levels were 105.8, 192, 134.2, 161, 157.75, 145.2 mg/dL. The conclusion of the results obtained was that 70% ethanol extract of fig leaves with a dose of 600 mg/kgBW can have an antidiabetic and obesity effect by lowering blood glucose levels as measured using glucometer, cholesterol strips and decreased body weight rats.

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Journal Info

Abbrev

jifi

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Description

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted ...