Efek Potensiasi Antibakteri Kombinasi Sefadroksil dan Ekstrak Daun Camellia sinensis (Kajian in vitro pada Enterococcus faecalis dan Staphylococcus aureus)

Didi Nugroho Santosa (Department of Pharmacology, Faculty of Dentistry, Universitas Trisakti, Indonesia)
Michelle (Undergraduate Student, Faculty of Dentistry, Universitas Trisakti, Indonesia)

Jurnal Kedokteran Gigi Terpadu
Vol. 5 No. 1 (2023): Jurnal Kedokteran Gigi Terpadu

Background: Periapical abscess caused by tooth necrosis which are not treated. Enterococcus faecalis and Staphylococcus aureus area found in periapical abscess. Cefadroxil is one of antibiotics that choices to treat this infection. Several studies proved that C. sinensis leaves extract contains metabolite compounds such as catechins that can inhibit bacterial growth. To determine the antibacterial effect of C. sinensis leaves extract and cefadroxil combination against E. faecalis dan S. aureus growth. Methods: Laboratory experimental research with diffusion method. The research design is post test only control group design. Treatment was carried out with C. sinensis leaves extract 125 mg/mL, combination of C. sinensis leaves extract 15,625 mg/mL, 31,25 mg/mL, 62,5 mg/mL and 125 mg/mL with cefadroxil 8 μg/mL , cefadroxil 16 μg/mL as a positive control, and NaOH 0.1 N as a negative control. Results: There was none of inhibition zone in C. sinensis leaves extract 125 mg/mL and NaOH 0.1 N. The combination of C. sinensis leaves extract 15,625 mg/mL, 31,25 mg/mL, 62,5 mg/mL and 125 mg/mL and cefadroxil 8 µg/mL had an antibacterial effect. Based on Post-hoc Tukey’s HSD test, there was no significant difference between the combination and positive control. Conclusion: C. sinensis leaves extract and cefadroxil has potentially antibacterial effect on E. faecalis and S. aureus.