East Asian Journal of Multidisciplinary Research (EAJMR)
Vol. 2 No. 9 (2023): September 2023

Type of Cosurfactant Effects on Particle Size in Nanoemulsion Drug Delivery Systems

Ike Widyaningrum (University of Islamic Malang (UNISMA))
Efriza Fahmi Triyoga (University of Islamic Malang (UNISMA))
Nugroho Wibisono (University of Islamic Malang (UNISMA))
Shinta Kusumawati (University of Islamic Malang (UNISMA))
Anita Puspa Widiyana (University of Islamic Malang (UNISMA))



Article Info

Publish Date
03 Oct 2023

Abstract

Nanoemulsions are thermodynamically or kinetically stable compared to conventional emulsions, and the particle size of nanoemulsions is around 5-200 nm. Until now, there has been no research comparing propylene glycol and PEG 400 cosurfactants for nanoemulsions, so it needs to be investigated. Laboratory experimental research with cosurfactant propylene glycol and PEG 400 Formula 1 and Formula 2 were repeated three times (n = 3) for each nanoemulsion formula. Parameters of physical properties (organoleptic, viscosity, particle size, index polydispersity) and chemical properties (pH). Evaluated and analyzed, <0.05 is considered significant. The results of formula 1 and formula 2 obtained the same clear organoleptic properties. The average particle size with cosurfactant propylene glycol was 10.41 ± 0.14 nm and PEG 400 was 12.32 ± 0.38 nm (p <0.05). The average viscosity, polydispersity index, and pH of propylene glycol were 8.72 ± 1.12; 0.03±0.02; 4.20 ± 0.04; and PEG 11.26 ± 1.80; 0.39 ± 0.58; 4.03±0.03. This shows that the type of cosurfactant has an effect on the size of the nanoemulsion particles.

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Journal Info

Abbrev

eajmr

Publisher

Subject

Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering

Description

East Asian Journal of Multidisciplinary Research (EAJMR) is a scientific multidisciplinary research journal published by Yayasan Pendidikan Penelitian Pengabdian Algero. The aim of this journal publication is to disseminate the research results, conceptual thoughts, improved research methodologies ...