Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves

Basile Goueti (1Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP : 4166 Cotonou, Benin)
Benedicta Kpadonou-Kpoviessi (1Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP : 4166 Cotonou, Benin 2Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Cala)
Raymond Fatondji (1Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP : 4166 Cotonou, Benin.)
Bardieu Atchade (1Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP : 4166 Cotonou, Benin.)
Paul Djouonzo Toukam (3Center for Studies on Medicinal Plants and Traditionnal Medicine (CRPMT) Institute of Medical Research and Medicinal plants Studies (IMPM), PO. Box 13033, yaoundé, Cameroon)
Salomé Dossou Sika KPOVIESSI (1Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP : 4166 Cotonou, Benin University of Abomey-Calavi (Benin))

The Journal of Pure and Applied Chemistry Research
Vol 12, No 2 (2023): May-August 2023

Rourea coccinea is a widely used medicinal plant worldwide, especially in West Africa. The phytochemical screening of the ethylanolic extract of leaves carried out according to the method of Houghton and Raman with some modifications, revealed the presence of alkaloids, phenolic compounds, terpenenoids, tannins, coumarines, anthocyanins and anthraquinones. The antiradicalar tests were performed using DPPH (2,2-diphenyl-1-picryhydrazyl), ABTS (2,2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diamum salt) and FRAP (Ferric Reducing Antioxidant Power) with a Scavenging concentration 50 (SC50) of 101,19 µg/mL, 34.73 µg/mL and 88.93 µg/mL respectively. The antishigella activity of the extract determined by the microdilution method was low. According to Jair Siquera-Neto et al., the antileishmanial assay using the colorimetric resealing method showed activity against promastigous strains of Leishmania donovani with an inhibitory concentration of IC50=32.26 µg/mL. The traditional use of Rourea coccinea, in the treatment of several diseases, would be justified by these pharmacological properties tested.