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All Journal The Journal of Pure and Applied Chemistry Research
Paul Djouonzo Toukam
3Center for Studies on Medicinal Plants and Traditionnal Medicine (CRPMT) Institute of Medical Research and Medicinal plants Studies (IMPM), PO. Box 13033, yaoundé, Cameroon
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves Basile Goueti; Benedicta Kpadonou-Kpoviessi; Raymond Fatondji; Bardieu Atchade; Paul Djouonzo Toukam; Salomé Dossou Sika KPOVIESSI
The Journal of Pure and Applied Chemistry Research Vol 12, No 2 (2023): May-August 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.02.3314

Abstract

Rourea coccinea is a widely used medicinal plant worldwide, especially in West Africa. The phytochemical screening of the ethylanolic extract of leaves carried out according to the method of Houghton and Raman with some modifications, revealed the presence of alkaloids, phenolic compounds, terpenenoids, tannins, coumarines, anthocyanins and anthraquinones. The antiradicalar tests were performed using DPPH (2,2-diphenyl-1-picryhydrazyl), ABTS (2,2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diamum salt) and FRAP (Ferric Reducing Antioxidant Power) with a Scavenging concentration 50 (SC50) of 101,19 µg/mL, 34.73 µg/mL and 88.93 µg/mL respectively. The antishigella activity of the extract determined by the microdilution method was low. According to Jair Siquera-Neto et al., the antileishmanial assay using the colorimetric resealing method showed activity against promastigous strains of Leishmania donovani with an inhibitory concentration of IC50=32.26 µg/mL. The traditional use of Rourea coccinea, in the treatment of several diseases, would be justified by these pharmacological properties tested.
Co-Authors Bardieu Atchade Basile Goueti Benedicta Kpadonou-Kpoviessi Raymond Fatondji Salomé Dossou Sika KPOVIESSI