<![CDATA[Background: Gingivitis is caused by a build up of plaque bacteria, one of which is Streptococcus sanguinis. Streptococcus sanguinis act as an anchor for the attachment of oral organisms that colonize the surface of the teeth, forming plaque so that it becomes the development of gingivitis. Currently, many natural ingredients, as alternatives, have antibacterial effects. One of which is Eusideroxylon zwageri, because it contains flavonoids, tannins, phenolics, saponins, alkaloids, and terpenoids. Purpose: to compare the inhibitory effect between ulin bark extract and Chlorhexidine gluconate 0.2% against Streptococcus sanguinis. Method: True experimental research with post test only with control group design using ulin bark extract concentrations of 20%, 40%, 60%, 80%, and 100% and Chlorhexidine gluconate 0.2% as the K(+). The maceration method was used to extract ulin bark while the inhibitory test was using the diffusion method with 6 treatment groups and 4 replications, so that there were 24 samples. All treatment groups were incubated 24 hours at 37oC then measurement of inhibition zones was using callipers. Results: The results of the test showed that ulin bark extract concentrations of 20%, 40%, 60%, 80%, 100%, and Chlorhexidine gluconate 0.2% obtained an average inhibition zone with diameter of 7.18 mm, 9.06 mm, 11.08 mm, 13 mm, 15.09 mm, and 18.14 mm. Analysis of One Way ANOVA and Post Hoc Games-Howell data showed a significant difference between treatment groups. Conclusion: Ulin bark extract can inhibit the growth of Streptococcus sanguinis but has not been able to equal to Chlorhexidine gluconate 0.2%. Keywords: Chlorhexidine gluconate 0,2%, gingivitis, inhibitory activity, ulin bark extract, Streptococcus sanguinis.]]>
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