Majalah Obat Tradisional
Vol 28, No 2 (2023)

Geographical Distribution, Chemical Constituents, and Activity Profile of Magnolia

Purabi Saha (Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand)
Supriyo Saha (Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, INDIA.)
Amit Semwal (College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand)
Prinsa Prinsa (Siddhartha Institute of Pharmacy, Sahastradhara Road Near IT-Park Dehradun 248001)
Tarun Parashar (Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand)
Vikash Jakhmola (Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand)



Article Info

Publish Date
31 Jul 2023

Abstract

Many Asian countries use the bark of the Magnolia for medicinal purposes. Magnolia has many medical uses, including regulating GI motility, treating cough and asthma, preventing cardiovascular disease, and treating mental illness and brain disorders. To date, 118 magnolia species have been discovered. However, the International Union for Conservation of Nature has designated 231 species as vulnerable and critically endangered. Magnolia leaves yielded 20 isolated chemicals, including 16 lignans with 6 distinct structural types, such as honokiol, veraguensin, sitosterol, and magliflonenone. Magnolia species show pharmacological activities like Neuroprotective, anti-cancer, Anti-microbial, Antiplatelets, Anti-asthmatic, Gastrointestinal, and Hormone regulation. Magnolia bark extracts such as honokiol 2',6-di-(5-propenyl)-1,1'-biphenyl-2,2'-diol, have been demonstrated to benefit health. In recent in vitro and preclinical research, honokiol was found to have anti-inflammatory, anti-angiogenic, anti-oxidative, and anti-cancer activities. Honokiol and magnolol prevented the thromboxane B2 synthesis in response to thrombin, arachidonic acid, and collagen. So, soon, if we cultivate and save the endangered magnolia species through biotechnological means, it will be a boon for mankind.

Copyrights © 2023






Journal Info

Abbrev

TradMedJ

Publisher

Subject

Health Professions Medicine & Pharmacology Public Health

Description

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, ...