DIFFERENCE OF BREAST CANCER ESTROGEN RECEPTOR (ER) BETWEEN OBESE PRE-MENOPAUSE WOMEN AND OBESE POST-MENOPAUSE WOMEN

Viqi Vincentius Julio (Faculty of Medicine, Widya Mandala Surabaya Catholic University)
Sindrawati Sindrawati (Department of Pathology Anatomy Faculty of Medicine, Widya Mandala Surabaya Catholic University)
Fransiscus Arifin (Department of Surgery Faculty of Medicine, Widya Mandala Surabaya Catholic University)

Journal Of Widya Medika Junior
Vol 5, No 3 (2023): July

Background: One of the risk of breast cancer is Obesity (BMI > 23Kg/m2) related to estrogen production between pre-menopause and post-menopause.Aim: To investigate the difference of breast cancer estrogen receptor (ER) in obese women based on menopausal status.Methods: This study was retrospective cross-sectional from secondary data (Medical Records) from Poliklinik Onkologi Satu Atap (POSA) RSUD Dr. Soetomo (ICD-10 C50) from 2013-2017 with inclusion criteria was BMI >23Kg/m2. Data were analyzed using Chi-Square.  Results: There were 138 patient medical records collected which is 63 were obese pre-menopause and 75 were obese post-menopause. There were statistically a significant difference (p<0,05) based on Chi square test of breast cancer estrogen receptor for obese post-menopause women (66,7%) to obese pre-menopause (39,7%). Obese post-menopause women have 1,68 times greater risk factor to become estrogen receptor positive (ER+) compared to obese pre-menopause women. (PR = 1,68; 95% CI = 1,191-2,370)  Conclusion : There is a significant difference of breast cancer estrogen receptor in obese post-menopause women more frequent than obese pre-menopause women.